Nanocarriers' entry into the cell: relevance to drug delivery

H Hillaireau, P Couvreur - Cellular and molecular life sciences, 2009 - Springer
Nanocarriers offer unique possibilities to overcome cellular barriers in order to improve the
delivery of various drugs and drug candidates, including the promising therapeutic …

Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery

E Gullotti, Y Yeo - Molecular pharmaceutics, 2009 - ACS Publications
One of the main goals of nanomedicine is to develop a nanocarrier that can selectively
deliver anticancer drugs to the targeted tumors. Extensive efforts have resulted in several …

Drug nanocarriers and functional nanoparticles: applications in cancer therapy

B Thierry - Current drug delivery, 2009 - ingentaconnect.com
Extending on recent progress in control of matter at the nanoscale, functional nanoparticles
and drug nanocarriers are being actively developed with the promise of improved delivery of …

On the cellular processing of non-viral nanomedicines for nucleic acid delivery: mechanisms and methods

D Vercauteren, J Rejman, TF Martens… - Journal of controlled …, 2012 - Elsevier
In the field of nanomedicine, ample attention has been paid to the development of
nanocarriers for the intracellular delivery of therapeutic cargo, such as nucleic acids for gene …

[HTML][HTML] Delivery systems for nucleic acids and proteins: Barriers, cell capture pathways and nanocarriers

JD Torres-Vanegas, JC Cruz, LH Reyes - Pharmaceutics, 2021 - mdpi.com
Gene therapy has been used as a potential approach to address the diagnosis and
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …

Endocytosis of nanomedicines

G Sahay, DY Alakhova, AV Kabanov - Journal of controlled release, 2010 - Elsevier
Novel nanomaterials are being developed to improve diagnosis and therapy of diseases
through effective delivery of drugs, biopharmaceutical molecules and imaging agents to …

[HTML][HTML] Endocytosis: the nanoparticle and submicron nanocompounds gateway into the cell

D Manzanares, V Ceña - Pharmaceutics, 2020 - mdpi.com
Nanoparticles (NPs) and submicron particles are increasingly used as carriers for delivering
therapeutic compounds to cells. Their entry into the cell represents the initial step in this …

[HTML][HTML] Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers

S Mazumdar, D Chitkara, A Mittal - Acta Pharmaceutica Sinica B, 2021 - Elsevier
The beneficial or deleterious effects of nanomedicines emerge from their complex
interactions with intracellular pathways and their subcellular fate. Moreover, the dynamic …

Actively targeted nanocarriers for drug delivery to cancer cells

S Biffi, R Voltan, B Bortot, G Zauli… - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Progressive breakthroughs in nanomedicine have been instrumental for the
clinical translation of actively targeted drug-delivery approaches. Besides storing large …

Nanopreparations for organelle-specific delivery in cancer

S Biswas, VP Torchilin - Advanced drug delivery reviews, 2014 - Elsevier
To efficiently deliver therapeutics into cancer cells, a number of strategies have been
recently investigated. The toxicity associated with the administration of chemotherapeutic …