Neuroinflammation and microglial activation are pathological markers of a number of central
nervous system (CNS) diseases. Chronic activation of microglia induces the release of …

Thymoquinone (TQ), the main pharmacological active ingredient within the black cumin
seed (Nigella sativa) is believed to be responsible for the therapeutic effects on chronic …

Both neuroinflammation and microglial activation are pathological markers of a number of
central nervous system (CNS) diseases. During chronic activation of the microglial cells, the …

Thymoquinone, the major active compound isolated from the medicinal Nigella sativa, has
been demonstrated to have anti-inflammatory activity. The aim of this study was to …

Microglia in the central nervous system (CNS) play an important role in the initiation of
neuroinflammatory response. Icariin, a compound from Epimedium brevicornum Maxim, has …

Alzheimer's disease (AD) is characterized by a robust inflammatory response elicited by the
accumulation and deposition of amyloid-β (Aβ) within the brain. Aβ induces detrimental …

Thymoquinone is a known inhibitor of neuroinflammation. However, the mechanism (s)
involved in its action remain largely unknown. In this study, we investigated the roles of …

Thymoquinone is an antioxidant phytochemical that has been shown to inhibit
neuroinflammation. However, little is known about the potential roles of intracellular …

Microglial cells are the prime effectors in immune and inflammatory responses of the central
nervous system (CNS). During pathological conditions, the activation of these cells helps …

Therapeutic strategies designed to inhibit the activation of microglia may lead to significant
advancement in the treatment of most neurodegenerative diseases. Pyrroloquinoline …