Endolysins are enzymes used by bacteriophages at the end of their replication cycle to
degrade the peptidoglycan of the bacterial host from within, resulting in cell lysis and release …

Bacteriophage endolysins have the potential to be a long-term antibacterial replacement for
antibiotics. The exogenous application of endolysins on some bacteria results in rapid cell …

One of the last untapped reservoirs in nature for the identification of new anti-microbials is
bacteriophages, the natural killers of bacteria. Lytic bacteriophages encode peptidoglycan …

There is growing concern about the emergence of bacterial strains showing resistance to all
classes of antibiotics commonly used in human medicine. Despite the broad range of …

Endolysins are phage-encoded enzymes that break down bacterial peptidoglycan at the
terminal stage of the phage reproduction cycle. Their action is tightly regulated by holins, by …

Endolysins are double-stranded DNA bacteriophage-encoded peptidoglycan hydrolases
produced in phage-infected bacterial cells toward the end of the lytic cycle. They reach the …

Highlights•Endolysins are promising novel therapeutics for treatment of bacterial
infections.•Endolysins can target infections in different organs and tissues of the human …

Endolysins are the lytic products of bacteriophages which play a specific role in the release
of phage progeny by degrading the peptidoglycan of the host bacterium. In the light of …

Peptidoglycan (PG) is the major structural component of the bacterial cell wall. Bacteria have
autolytic PG hydrolases that allow the cell to grow and divide. A well-studied group of PG …

Bacteriophage‐encoded endolysins can recognize and bind specific bacteria, and act to
cleave the glycosidic and/or amide bonds in the peptidoglycan (PG) bacterial cell wall …