This article discloses a new horizon for the application of peroxides in medical chemistry.
Stable cyclic peroxides are demonstrated to have cytotoxic activity against cancer cells; in …

Twenty six peroxides belonging to bridged 1, 2, 4, 5‐tetraoxanes, bridged 1, 2, 4‐trioxolanes
(ozonides), and tricyclic monoperoxides were evaluated for their in vitro antimalarial activity …

Bridged aminoperoxides, for the first time, were investigated for the in vitro antimalarial
activity against the chloroquine‐resistant Plasmodium falciparum strain K1 and for their …

The discovery of artemisinin in 1971 initiated a new era in antimalarial chemotherapy.
Although the clinically useful semisynthetic artemisinin derivatives are rapid acting and …

Synthetic ozonides and tetraoxanes were shown to have high cytotoxicity in vitro when
tested on androgen-independent prostate cancer cell lines DU145 and PC3, which is in …

A series of novel steroidal 5α, 8α-endoperoxide derivatives bearing semicarbazone (7a–g)
or thiosemicarbazone (7h–k) side chain were designed, synthesized and evaluated for their …

Present review describes research on novel natural anticancer agents isolated from
terrestrial and marine sources. More than 120 cytotoxic anticancer compounds have shown …

The problem of endemic malaria continues unabated globally. Malaria affects 40% of the
global population, causing an estimated annual mortality of 1.5-2.7 million people. The …

Building on insights gained from the discovery of the antimalarial ozonide arterolane
(OZ277), we now describe the structure–activity relationship (SAR) of the antimalarial …

Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a
single-dose oral cure in humans. OZ439 has successfully completed Phase I clinical trials …