Drives Blunted by Time: The Effects of Aging on Motivational Behaviors and Responses to Social Isolation in Mice

HC Lei - 2023 - search.proquest.com
Mental health in the elderly is an escalating social problem as the world population ages
rapidly. Older adults are more susceptible to stressors like social isolation, which is a …

[HTML][HTML] Emotional behavior in middle-aged rats: implications for geriatric psychopathologies

M Moretti, AG de Souza, G de Chaves… - Physiology & …, 2011 - Elsevier
Clinical findings reveal that middle-aged patients are more susceptible to suffer from
psychiatric disorders than older ones. However, little is known about the emotional behavior …

Aging and the social-emotional brain

E Soria-Gómez, J Piriz, I Torres-Alemán - Frontiers in Aging …, 2024 - frontiersin.org
In modern society, life expectancy increases year after year due in part to medical and
scientific advances. However, at the same time, other pathological conditions appear in …

Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging

HM Buechel, J Popovic, K Staggs… - Frontiers in aging …, 2014 - frontiersin.org
Cognitive processes associated with prefrontal cortex and hippocampus decline with age
and are vulnerable to disruption by stress. The stress/stress hormone/allostatic load …

Social isolation stress impairs passive avoidance learning in senescence-accelerated mouse (SAM)

Y Chida, N Sudo, J Mori, C Kubo - Brain research, 2006 - Elsevier
Despite cumulative evidence showing the detrimental effect of psychosocial stress on the
learning/memory functions in dementia diseases, the precise neurobiological mechanisms …

Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates

A Lotan, T Lifschytz, G Wolf, S Keller, H Ben-Ari… - Molecular …, 2018 - nature.com
Stress-related psychopathology is highly prevalent among elderly individuals and is
associated with detrimental effects on mood, appetite and cognition. Conversely, under …

Reduced activity of glutamatergic neurons in the prelimbic medial prefrontal cortex underlies the inherent aging-related physiological reduction in social dominance

Q Shan, X Lin, X Yu, W Guo… - The Journals of …, 2023 - academic.oup.com
Human society is aging, and the percentage of the population of older adults is increasing at
an unprecedented rate. It is increasingly appreciated that social behaviors change with …

Deficits in social behavior precede cognitive decline in middle-aged mice

F Boyer, F Jaouen, EC Ibrahim… - Frontiers in Behavioral …, 2019 - frontiersin.org
An extensive literature details deterioration of multiple brain functions, especially memory
and learning, during aging in humans and in rodents. In contrast, the decline of social …

Parallel declines in cognition, motivation, and locomotion in aging mice: association with immune gene upregulation in the medial prefrontal cortex

KA Bordner, RR Kitchen, B Carlyle, ED George… - Experimental …, 2011 - Elsevier
Aging in humans is associated with parallel changes in cognition, motivation, and motoric
performance. Based on the human aging literature, we hypothesized that this constellation …

Age-related decrease in stress responsiveness and proactive coping in male mice

HJ Oh, M Song, YK Kim, JR Bae, SY Cha… - Frontiers in aging …, 2018 - frontiersin.org
Coping is a strategic approach to dealing with stressful situations. Those who use proactive
coping strategies tend to accept changes and act before changes are expected. In contrast …