Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in
insulin resistance. However, disentangling the individual roles of these processes in insulin …

Adipocyte function is crucial for the control of whole body energy homeostasis. Pathway
analysis of differentiating 3T3-L1 adipocytes reveals that major metabolic pathways induced …

Insulin resistance is associated with mitochondrial dysfunction, but the mechanism by which
mitochondria inhibit insulin-stimulated glucose uptake into the cytoplasm is unclear. The …

Chronic overnutrition and physical inactivity are major risk factors for insulin resistance and
type 2 diabetes. Recent research indicates that overnutrition generates an increase in …

Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

Insulin resistance is one of the earliest pathological features of a suite of diseases including
type 2 diabetes collectively referred to as metabolic syndrome. There is a growing body of …

The specific cellular underpinnings or mechanisms of insulin resistance (IR) are not clear.
Here I present evidence to support a causal association between mitochondrial energetics …

The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …

The contribution of mitochondrial dysfunction to insulin resistance is a contentious issue in
metabolic research. Recent evidence implicates mitochondrial dysfunction as contributing to …