The STING1 network regulates autophagy and cell death
Cell death and immune response are at the core of life. In past decades, the endoplasmic
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
STING directly activates autophagy to tune the innate immune response
STING (stimulator of interferon genes) is a central molecule that binds to cyclic dinucleotides
produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against …
produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against …
A conserved ion channel function of STING mediates noncanonical autophagy and cell death
The cGAS/STING pathway triggers inflammation upon diverse cellular stresses such as
infection, cellular damage, aging, and diseases. STING also triggers noncanonical …
infection, cellular damage, aging, and diseases. STING also triggers noncanonical …
Trafficking-mediated STING degradation requires sorting to acidified endolysosomes and can be targeted to enhance anti-tumor response
VK Gonugunta, T Sakai, V Pokatayev, K Yang, J Wu… - Cell reports, 2017 - cell.com
STING is an endoplasmic reticulum (ER)-associated transmembrane protein that turns on
and quickly turns off downstream signaling as it translocates from the ER to vesicles. How …
and quickly turns off downstream signaling as it translocates from the ER to vesicles. How …
Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases
P Hou, Y Lin, Z Li, R Lu, Y Wang, T Tian, P Jia… - Cellular & Molecular …, 2021 - nature.com
DNA sensing and timely activation of interferon (IFN)-mediated innate immunity are crucial
for the defense against DNA virus infections and the clearance of abnormal cells. However …
for the defense against DNA virus infections and the clearance of abnormal cells. However …
UNC93B1 attenuates the cGAS–STING signaling pathway by targeting STING for autophagy–lysosome degradation
H Zhu, R Zhang, L Yi, YD Tang… - Journal of Medical …, 2022 - Wiley Online Library
Stimulator of interferon genes (STING) is a pivotal innate immune adaptor, and its functions
during DNA virus infections have been extensively documented. However, its homeostatic …
during DNA virus infections have been extensively documented. However, its homeostatic …
The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
L Kong, C Sui, T Chen, L Zhang, W Zhao, Y Zheng… - Cell Reports, 2023 - cell.com
STING is an endoplasmic reticulum-resident protein regulating innate immunity. After
binding with cyclic guanosine monophosphate-AMP (cGAMP), STING translocates from the …
binding with cyclic guanosine monophosphate-AMP (cGAMP), STING translocates from the …
[HTML][HTML] STING senses microbial viability to orchestrate stress-mediated autophagy of the endoplasmic reticulum
Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity
and comprises primordial innate defense. Phagocytes mobilize interferon-inducible …
and comprises primordial innate defense. Phagocytes mobilize interferon-inducible …
STING controls energy stress-induced autophagy and energy metabolism via STX17
The stimulator of interferon genes (STING) plays a critical role in innate immunity. Emerging
evidence suggests that STING is important for DNA or cGAMP-induced non-canonical …
evidence suggests that STING is important for DNA or cGAMP-induced non-canonical …
STING signaling promotes apoptosis, necrosis, and cell death: an overview and update
S Liu, W Guan - Mediators of Inflammation, 2018 - Wiley Online Library
STING is a newly identified intracellular sensor of foreign and endogenous DNA. STING has
been recognized as an activator of immune responses by TBK1/IRF3 and NF‐κB pathways …
been recognized as an activator of immune responses by TBK1/IRF3 and NF‐κB pathways …