Orderly replication of DNA is a prerequisite to the faithful segregation of the chromosomes
before cell division. These processes occur in an environment where the natural order of …

The fidelity of DNA replication is of paramount importance to the maintenance of genome
integrity. When an active replication fork is perturbed, multiple cellular pathways are …

Chromosome replication is not a uniform and continuous process. Replication forks can be
slowed down or arrested by DNA secondary structures, specific protein-DNA complexes …

The arrest of DNA replication by DNA damage, nucleotide depletion, DNA–protein
complexes or following clashes between transcription and replication factors all have the …

Defects in chromosome replication can lead to translocations that are thought to result from
recombination events at stalled DNA replication forks. The progression of forks is controlled …

Replication arrests are associated with genome rearrangements, which result from either
homologous or non-homologous recombination. Interestingly, proteins involved in …

Impairment of replication fork progression is a serious threat to living organisms and a
potential source of genome instability. Studies in prokaryotes have provided evidence that …

Accurate and complete replication of the genome in every cell division is a prerequisite of
genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely …

DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and
checkpoint pathways. Here, we discuss recent advances in understanding how replication is …

Single-molecule analyses of DNA replication have greatly advanced our understanding of
mammalian replication restart. Several proteins that are not part of the core replication …