Insight into the roles of CCR5 in learning and memory in normal and disordered states
As cognitive impairments continue to rise in prevalence, there is an urgent need to
understand the mechanisms of learning and memory in normal and disordered states. C–C …
understand the mechanisms of learning and memory in normal and disordered states. C–C …
CCR5 regulates Aβ1-42-induced learning and memory deficits in mice
HY Huang, S Salinas, J Cornell, IB Udoh… - … of Learning and …, 2024 - Elsevier
Abstract C–C chemokine receptor 5 (CCR5) is a chemokine receptor involved in immune
responses and a co-receptor for HIV infection. Recently, CCR5 has also been reported to …
responses and a co-receptor for HIV infection. Recently, CCR5 has also been reported to …
CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory
Although the role of CCR5 in immunity and in HIV infection has been studied widely, its role
in neuronal plasticity, learning and memory is not understood. Here, we report that …
in neuronal plasticity, learning and memory is not understood. Here, we report that …
Pharmacological blockers of CCR5 and CXCR4 improve recovery after traumatic brain injury
Y Friedman-Levi, S Liraz-Zaltsman, C Shemesh… - Experimental …, 2021 - Elsevier
CCR5 and CXCR4 are structurally related chemokine receptors that belong to the
superfamily of G-protein coupled receptors through which the HIV virus enters and infects …
superfamily of G-protein coupled receptors through which the HIV virus enters and infects …
[HTML][HTML] Brain-derived CCR5 contributes to neuroprotection and brain repair after experimental stroke
Abstract Chemokine (CC motif) receptor 5 (CCR5) is expressed not only in the immune cells
but also in cerebral cells such as neurons, glia, and vascular cells. Stroke triggers high …
but also in cerebral cells such as neurons, glia, and vascular cells. Stroke triggers high …
The chemokine receptor CCR5 in the central nervous system
The expression and the role of the chemokine receptor CCR5 have been mainly studied in
the context of HIV infection. However, this protein is also expressed in the brain, where it can …
the context of HIV infection. However, this protein is also expressed in the brain, where it can …
Chemokine receptors CC chemokine receptor 5 and CXC motif chemokine receptor 4 are new therapeutic targets for brain recovery after traumatic brain injury
S Liraz-Zaltsman, Y Friedman-Levi… - Journal of …, 2021 - liebertpub.com
Recently, chemokine receptor CC chemokine receptor 5 (CCR5) was found to be a negative
modulator of learning and memory. Its inhibition improved outcome after stroke and …
modulator of learning and memory. Its inhibition improved outcome after stroke and …
The role of CCR5 in HIV-associated neurocognitive disorders
While combination antiretroviral therapy (cART) has successfully increased the lifespan of
individuals infected with HIV, a significant portion of this population remains affected by HIV …
individuals infected with HIV, a significant portion of this population remains affected by HIV …
[HTML][HTML] CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury
MT Joy, EB Assayag, D Shabashov-Stone… - Cell, 2019 - cell.com
We tested a newly described molecular memory system, CCR5 signaling, for its role in
recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical …
recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical …
CCR5 deficiency induces astrocyte activation, Aβ deposit and impaired memory function
YK Lee, DH Kwak, KW Oh, SY Nam, BJ Lee… - Neurobiology of learning …, 2009 - Elsevier
Activation of astrocytes has been known to be associated with amyloid-beta (Aβ) deposit
and production of pro-inflammatory cytokines and chemokines that lead to neuronal cell …
and production of pro-inflammatory cytokines and chemokines that lead to neuronal cell …