During angiogenesis, endothelial cells (ECs) from intact blood vessels quickly infiltrate
avascular regions via vascular sprouting. This process is fundamental to many normal and …

The density and architecture of capillary beds that form within a tissue depend on many
factors, including local metabolic demand and blood flow. Here, using microfluidic control of …

Endothelial cell (EC) sprouting morphogenesis is a critical step during angiogenesis, the
formation of new blood vessels from existing conduits. Here, three-dimensional sprouting …

The endothelium is the cell monolayer that lines the interior of the blood vessels separating
the vessel lumen where blood circulates, from the surrounding tissues. During embryonic …

Identifying the mechanisms regulating angiogenesis in pathological conditions such as
cancer and heart disease is crucial to develop successful therapies. The dependence of …

Angiogenic sprouting, the growth of new blood vessels from pre-existing vessels, is
orchestrated by cues from within the cellular microenvironment, such as biochemical …

Mechanical signals regulate blood vessel development in vivo, and have been
demonstrated to regulate signal transduction of endothelial cell (EC) and smooth muscle cell …

During angiogenesis, anastomosing capillary sprouts align to form complex three-
dimensional networks of new blood vessels. Using an endothelial cell spheroid model that …

Vascular remodeling under conditions of growth or exercise, or during recovery from arterial
restriction or blockage is essential for health, but mechanisms are poorly understood. It has …

Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into
biochemical signals that regulate gene expression and cell behavior via specialized …