The central dogma of gene expression is that DNA is transcribed into messenger RNAs,
which in turn serve as the template for protein synthesis. The discovery of extensive …

The increased application of transcriptome-wide profiling approaches has led to an
explosion in the number of documented long non-coding RNAs (lncRNAs). While these new …

A major shift in our understanding of genome regulation has emerged recently. It is now
apparent that the majority of cellular transcripts do not code for proteins, and many of them …

Genomes of complex organisms encode an abundance and diversity of long noncoding
RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide variety of regulatory …

We have known for decades that long noncoding RNAs (lncRNAs) can play essential
functions across most forms of life. The maintenance of chromosome length requires an …

Numerous studies over the past decade have identified increasing numbers of long
noncoding RNAs (lncRNAs) across many organisms. Research since has shown that …

Long non-coding RNAs (lncRNAs) are increasingly being recognized as epigenetic
regulators of gene transcription. The diversity and complexity of lncRNA genes means that …

Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found
throughout the cell that lack protein‐coding function. Their functions are closely linked to …