Antiviral therapy for COVID-19: Derivation of optimal strategy based on past antiviral and favipiravir experiences

K Shiraki, N Sato, K Sakai, S Matsumoto… - Pharmacology & …, 2022 - Elsevier
Favipiravir, a broad-spectrum RNA-dependent RNA polymerase inhibitor, inhibits the
replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at …

[HTML][HTML] Favipiravir and COVID-19: a simplified summary

M Ghasemnejad-Berenji, S Pashapour - Drug research, 2021 - thieme-connect.com
A recent outbreak of coronavirus disease 2019 (COVID-19) caused by the novel coronavirus
designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in …

Understanding the clinical utility of favipiravir (T-705) in coronavirus disease of 2019: A review

K Srinivasan, M Rao - Therapeutic Advances in Infectious …, 2021 - journals.sagepub.com
The coronavirus disease of 2019 (COVID-19) has caused significant morbidity and mortality
among infected individuals across the world. High transmissibility rate of the causative virus …

[HTML][HTML] Efficacy and safety of favipiravir in moderate COVID-19 pneumonia patients without oxygen therapy: a randomized, phase III clinical trial

M Shinkai, K Tsushima, S Tanaka, E Hagiwara… - Infectious diseases and …, 2021 - Springer
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), is an enveloped, single-stranded RNA virus …

Favipiravir: pharmacokinetics and concerns about clinical trials for 2019‐nCoV infection

YX Du, XP Chen - Clinical Pharmacology & Therapeutics, 2020 - Wiley Online Library
An outbreak of 2019‐nCoV infection has spread across the world. No specific antiviral drugs
have been approved for the treatment of COVID‐2019. In addition to the recommended …

[HTML][HTML] Mechanism of action of favipiravir against SARS-CoV-2: Mutagenesis or chain termination?

L Zhao, W Zhong - The Innovation, 2021 - cell.com
Favipiravir is a novel broad-spectrum antiviral drug against RNA viruses that has been
approved for the treatment of seasonal and pandemic influenza. The use of favipiravir is a …

[HTML][HTML] Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: A randomized, comparative, open-label …

ZF Udwadia, P Singh, H Barkate, S Patil… - International Journal of …, 2021 - Elsevier
Objective To assess the efficacy and safety of favipiravir in adults with mild-to-moderate
coronavirus disease 2019 (COVID-19). Methods In this randomized, open-label, parallel …

[HTML][HTML] Role of favipiravir in the treatment of COVID-19

S Joshi, J Parkar, A Ansari, A Vora, D Talwar… - International Journal of …, 2021 - Elsevier
Abstract The coronavirus disease-2019 (COVID-19) outbreak all over the world has led the
researchers to strive to develop drugs or vaccines to prevent or halt the progression of this …

[HTML][HTML] Favipiravir versus other antiviral or standard of care for COVID-19 treatment: a rapid systematic review and meta-analysis

DB Shrestha, P Budhathoki, S Khadka, PB Shah… - Virology journal, 2020 - Springer
Background The COVID-19 causing coronavirus is an enveloped RNA virus that utilizes an
enzyme RNA dependent RNA polymerase for its replication. Favipiravir (FVP) triphosphate …

Favipiravir for treatment of outpatients with asymptomatic or uncomplicated coronavirus disease 2019: a double-blind, randomized, placebo-controlled, phase 2 trial

M Holubar, A Subramanian, N Purington… - Clinical Infectious …, 2022 - academic.oup.com
Background Favipiravir, an oral, RNA-dependent RNA polymerase inhibitor, has in vitro
activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite …