Background Several genes encoding transcription factors are known to be the primary
cause of congenital heart disease. NKX2‐5 and GATA4 were the first congenital heart …

Congenital heart disease (CHD) is one of the most common birth defects in humans.
Mutations in cardiac transcription factor genes, such as GATA4, NKX2-5 and TBX5 genes …

The ventricular septal defect (VSD) is the most common type of congenital heart disease
(CHD). The morbidity and mortality of CHD patients are significantly higher due to late …

Background. Variants of several genes encoding transcription modulators, signal
transduction, and structural proteins are known to cause Mendelian congenital heart …

Congenital heart disease (CHD), one of the causes of childhood morbidity and mortality, is
mainly triggered by a combination of environmental and genetic factors. Several susceptible …

Congenital heart diseases (CHD) are the most common anomalies that occur during heart
embryogenesis and are associated with significant mortality and morbidity in infants. It has …

Congenital heart disease (CHD) is the most common birth defect occurring in humans and
some transcriptional factors have been identified as causative. However, additional mutation …

Congenital heart disease (CHD) is a common congenital birth defect, affecting nearly 1% of
all live births, and is the most common cause of infant death. NKX2. 5 is an important …

Background and Aim: Mutations in the NKX2. 5 gene, a cardiac transcription factor, have
been implicated in various types of congenital heart defects (CHD) and it is known that …

Congenital heart disease (CHD) usually occurs sporadically, with only a minority of cases
associated with a known genetic mechanism. Cardiac-specific transcription factors NKX2-5 …