Modern epigenetics methods in biological research

Y Li - Methods, 2021 - Elsevier
The definition of epigenetics refers that molecular modifications on DNA that can regulate
gene activity are independent of DNA sequence and mitotically stable. Notably, epigenetics …

[HTML][HTML] Mapping epigenetic modifications by sequencing technologies

X Chen, H Xu, X Shu, CX Song - Cell Death & Differentiation, 2023 - nature.com
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …

Introduction to epigenomics and epigenome-wide analysis

MJ Fazzari, JM Greally - Statistical Methods in Molecular Biology, 2010 - Springer
Epigenetics is the study of heritable change other than those encoded in DNA sequence.
Cytosine methylation of DNA at CpG dinucleotides is the most well-studied epigenetic …

[HTML][HTML] DNA methylation analysis: choosing the right method

S Kurdyukov, M Bullock - Biology, 2016 - mdpi.com
In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

Hunting for the 5th base: Techniques for analyzing DNA methylation

O Ammerpohl, JI Martín-Subero, J Richter… - … et Biophysica Acta (BBA …, 2009 - Elsevier
BACKGROUND: In the recent past large progress has been made in the analysis of the
epigenome, the entirety of epigenetic modifications, and its meaning for the implementation …

Next‐generation technologies and data analytical approaches for epigenomics

K Mensaert, S Denil, G Trooskens… - Environmental and …, 2014 - Wiley Online Library
Epigenetics refers to the collection of heritable features that modulate the genome–
environment interaction without being encoded in the actual DNA sequence. While being …

Principles and challenges of genome-wide DNA methylation analysis

PW Laird - Nature Reviews Genetics, 2010 - nature.com
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

Methods in DNA methylation profiling

T Zuo, B Tycko, TM Liu, HJL Lin, THM Huang - Epigenomics, 2009 - Taylor & Francis
Metastable and somatically heritable patterns of DNA methylation provide an important level
of genomic regulation. In this article, we review methods for analyzing these genome-wide …

[HTML][HTML] Epigenetic changes in cancer

M Esteller - F1000 biology reports, 2011 - ncbi.nlm.nih.gov
Interest in epigenetics is now booming in all the biomedical fields. Initially, interest was
sparked within the field of cancer research with the finding of global DNA hypomethylation …

Epigenomics: genome-wide study of methylation phenomena

KL Novik, I Nimmrich, B Genc, S Maier… - Current issues in …, 2002 - mdpi.com
Epigenetics is one of the key areas of future research that can elucidate how genomes work.
It combines genetics and the environment to address complex biological systems such as …