Phenotypic changes in dorsal root ganglion and spinal cord in the collagen antibody‐induced arthritis mouse model

J Su, T Gao, T Shi, Q Xiang, X Xu… - Journal of …, 2015 - Wiley Online Library
The mechanisms underlying rheumatoid arthritis (RA)‐induced pain are still not fully
elucidated, and accumulating data indicate that peripheral inflammation is not the only factor …

Neuron-immune mechanisms contribute to pain in early stages of arthritis

FR Nieto, AK Clark, J Grist, GJ Hathway… - Journal of …, 2016 - Springer
Background Rheumatoid arthritis (RA) patients frequently show weak correlations between
the magnitude of pain and inflammation suggesting that mechanisms other than overt …

Collagen antibody–induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency

DB Bas, J Su, K Sandor, NM Agalave… - Arthritis & …, 2012 - Wiley Online Library
Objective Pain is one of the most debilitating symptoms reported by rheumatoid arthritis (RA)
patients. While the collagen antibody–induced arthritis (CAIA) model is used for studying the …

Calcitonin Gene‐Related Peptide–Expressing Sensory Neurons and Spinal Microglial Reactivity Contribute to Pain States in Collagen‐Induced Arthritis

FR Nieto, AK Clark, J Grist, V Chapman… - Arthritis & …, 2015 - Wiley Online Library
Objective To evaluate the contribution of sensory neurons in ankle joints and adjacent tissue
to the development of pain in collagen‐induced arthritis (CIA), and to determine the …

Collagen‐induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade

JJ Inglis, CA Notley, D Essex, AW Wilson… - … : Official Journal of …, 2007 - Wiley Online Library
Objective There is a disparity in the animal models used to study pain in rheumatoid arthritis
(RA), which tends to be acute in nature, and models used to assess the pathogenesis of RA …

Peripheral and central nervous system alterations in a rat model of inflammatory arthritis

S Locke, N Yousefpour, M Mannarino, S Xing… - Pain, 2020 - journals.lww.com
It is consistently reported that in inflammatory arthritis (IA), pain may continue despite well-
controlled inflammation, most likely due to interactions between joint pathology and pain …

Phenotypic alterations of neurons that innervate osteoarthritic joints in rats

J Ferreira‐Gomes, S Adães, J Sarkander… - Arthritis & …, 2010 - Wiley Online Library
Objective Pain is a prominent feature of osteoarthritis (OA). To further understand the
primary mechanisms of nociception in OA, we studied the expression of the phenotype …

Animal models of rheumatoid pain: experimental systems and insights

BD Fischer, A Adeyemo, ME O'Leary… - Arthritis research & …, 2017 - Springer
Severe chronic pain is one of the hallmarks and most debilitating manifestations of
inflammatory arthritis. It represents a significant problem in the clinical management of …

Osteoarthritis pain: what are we learning from animal models?

RE Miller, AM Malfait - Best Practice & Research Clinical Rheumatology, 2017 - Elsevier
All experimental models of osteoarthritis (OA)-like joint damage are accompanied by
behaviors indicative of pain. In experimental knee OA, evoked pain responses to …

Effects of differently activated rodent macrophages on sensory neurons: implications for arthritis pain

J Massier, A Eitner… - Arthritis & …, 2015 - Wiley Online Library
Objective In arthritis, macrophages invade the affected joint. Experimental arthritis models
have shown that macrophages also invade the dorsal root ganglia (DRGs) of the inflamed …