Introduction: Since years, ligands blocking histamine H3 receptor (H3R) activity
(antagonists/inverse agonists) are interesting targets in the search for new cures for CNS …

Importance of the field: Histamine H3 receptor (H3R) antagonists/inverse agonists can be
therapeutically useful in the treatment of various CNS, metabolic syndrome and allergic …

Introduction: Histamine H3 receptor (H3R) is involved in the central and peripheral
regulation of levels of histamine and other neurotransmitters (eg, acetylcholine …

Introduction: The histamine H3 receptor (H3R) plays a pivotal role in a plethora of
therapeutic areas. Blocking the H3R with antagonists/inverse agonists has been postulated …

The neurotransmitter histamine exerts its action through four distinct histamine receptors.
The histamine H1 and H2 receptor are well established drug targets, whereas the histamine …

This article describes our efforts along with recent advances in the development, biological
evaluation and clinical proof of concept of small molecule histamine H3 antagonists/inverse …

With the very recent market approval of pitolisant (Wakix®), the interest in clinical
applications of novel multifunctional histamine H3 receptor antagonists has clearly …

The histamine H3 receptor is involved in the central and peripheral regulation of levels of
histamine and other neurotransmitters (eg, acetylcholine, noradrenaline, dopamine …

Since the discovery of the histamine H 3 receptor in 1983, tremendous advances in the
pharmacological aspects of H 3 receptor antagonists/inverse agonists have been …

The histamine H3 receptor plays a regulatory role in the pre-synaptic release of histamine
and other neurotransmitters, making it an attractive target for CNS indications including …