Based on the mimicry of microbial metabolites, functionalized indoles were demonstrated as
the ligands and agonists of the pregnane X receptor (PXR). The lead indole, FKK6 …

The human PXR (pregnane X receptor), a master regulator of drug metabolism, has
essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands …

Microbial metabolite mimicry is a new concept that promises to deliver compounds that have
minimal liabilities and enhanced therapeutic effects in a host. In a previous publication, we …

Pregnane X receptor (PXR) plays roles in detoxification and other physiological processes.
PXR activation may enhance drug metabolism (leading to adverse drug reactions) or inhibit …

The pregnane X receptor (PXR; NR1I2) is an important nuclear receptor whose main
function is to regulate enzymes within drug metabolism. The main drug metabolizing …

The pregnane X receptor (PXR) is a nuclear receptor (NR) that primarily activates genes
involved in drug metabolism. However, PXR also suppresses inflammation. This study …

Recently, we reported the identification of a novel class of pregnane-X-receptor (PXR)
agonists, solomonsterols A and B, isolated from the marine sponge Theonella swinhoei …

It is well-known that the pregnane X receptor (PXR)/Nr1i2 is a critical xenobiotic-sensing
nuclear receptor enriched in liver and intestine and is responsible for drug-drug interactions …

The inflammatory bowel diseases (IBDs) are chronic inflammatory disorders with a complex
etiology. IBD is thought to arise in genetically susceptible individuals in the context of …

The intestinal epithelial barrier plays a key role in the maintenance of homeostasis within the
gastrointestinal tract. Barrier dysfunction leading to increased epithelial permeability is …