The endothelium, once considered a mere selectively permeable barrier between the
bloodstream and the outer vascular wall, is now recognized to be a crucial homeostatic …

Type 2 diabetes is characterized by a two-to fourfold increased risk of cardiovascular
disease. This is generally attributed to the adverse effects of hyperglycemia and oxidative …

Studies in man Antonio Ceriello (Udine, Italy) discussed the role of glucose intake and
postprandial hyperglycemia in the development of diabetes complications, as well as the …

The endothelium is a thin monocelular layer that covers all the inner surface of the blood
vessels, separating the circulating blood from the tissues. It is not an inactive organ, quite the …

The endothelium produces multiple mediators that not only regulate blood pressure, but also
important physiological inflammatory processes such as the recruitment and activation of …

AIMS: Vascular endothelial cells play a major role in maintaining cardiovascular
homeostasis in health. Diabetes mellitus (DM) substantially impairs the vasodilating …

Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes
(T1DM). Although there is a clear association between endothelial dysfunction and …

Objective—Defective NO release/response may contribute to increased coronary risk and
the loss of sex difference in coronary heart disease in diabetes. We aimed to determine …

Diabetes mellitus and impaired glucose tolerance are linked to increased cardiovascular
morbidity and mortality. Vascular disease is directly associated with plasma glucose levels …

Diabetes mellitus is associated with accelerated atherosclerosis and an increased
prevalence of cardiovascular disease. Although the link between diabetes and …