Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint
The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the
stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a …
stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a …
Mechanistic basis of co-stimulatory CD40-CD40L ligation mediated regulation of immune responses in cancer and autoimmune disorders
Generation of an accurate humoral and a cell mediated adaptive immune responsesare
dictated by binding of an antigen to a T-and a B-cell receptor, respectively (first signal) …
dictated by binding of an antigen to a T-and a B-cell receptor, respectively (first signal) …
What is the real role of CD40 in cancer immunotherapy?
RT Costello, JA Gastaut, D Olive - Immunology today, 1999 - cell.com
Abstract The CD40–CD40 ligand (CD40L) system is of pivotal importance in the immune
response via interactions between T cells and antigen-presenting cells. Recent reports have …
response via interactions between T cells and antigen-presenting cells. Recent reports have …
Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges
CL Law, IS Grewal - Therapeutic targets of the TNF superfamily, 2009 - Springer
CD40 was originally identified as a receptor on B-cells that delivers contact-dependent T
helper signals to B-cells through interaction with CD40 ligand (CD40L, CD154). The pivotal …
helper signals to B-cells through interaction with CD40 ligand (CD40L, CD154). The pivotal …
Molecular mechanism and function of CD40/CD40L engagement in the immune system
R Elgueta, MJ Benson, VC De Vries… - Immunological …, 2009 - Wiley Online Library
During the generation of a successful adaptive immune response, multiple molecular
signals are required. A primary signal is the binding of cognate antigen to an antigen …
signals are required. A primary signal is the binding of cognate antigen to an antigen …
[HTML][HTML] Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond
JL Karnell, SA Rieder, R Ettinger, R Kolbeck - Advanced drug delivery …, 2019 - Elsevier
CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …
The immune revolution: a case for priming, not checkpoint
RH Vonderheide - Cancer cell, 2018 - cell.com
Most tumors are unresponsive to immune checkpoint blockade, especially if deep
immunosuppression in the tumor develops prior to and prevents T cell immunosurveillance …
immunosuppression in the tumor develops prior to and prevents T cell immunosurveillance …
Prospect of targeting the CD40 pathway for cancer therapy
RH Vonderheide - Clinical cancer research, 2007 - AACR
The cell surface molecule CD40 is a member of the tumor necrosis factor receptor
superfamily and is broadly expressed by immune, hematopoietic, vascular, epithelial, and …
superfamily and is broadly expressed by immune, hematopoietic, vascular, epithelial, and …
Concepts for agonistic targeting of CD40 in immuno-oncology
DM Richards, JP Sefrin, C Gieffers, O Hill… - Human vaccines & …, 2020 - Taylor & Francis
ABSTRACT TNF Receptor Superfamily (TNF-R-SF) signaling is a structurally well-defined
event that requires proper receptor clustering and trimerization. While the TNF-SF ligands …
event that requires proper receptor clustering and trimerization. While the TNF-SF ligands …
CD40 agonist antibodies in cancer immunotherapy
RH Vonderheide - Annual review of medicine, 2020 - annualreviews.org
CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily.
Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and …
Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and …