Molecular mechanisms of metabotropic GABAB receptor function
Metabotropic γ-aminobutyric acid G protein–coupled receptors (GABAB) represent one of
the two main types of inhibitory neurotransmitter receptors in the brain. These receptors act …
the two main types of inhibitory neurotransmitter receptors in the brain. These receptors act …
Structural basis for activation of the heterodimeric GABAB receptor
Y Kim, E Jeong, JH Jeong, Y Kim, Y Cho - Journal of molecular biology, 2020 - Elsevier
The neurotransmitter γ-aminobutyric acid (GABA) activates the metabotropic GABA B
receptor to generate slow, prolonged inhibitory signals that regulate the neural circuitry. The …
receptor to generate slow, prolonged inhibitory signals that regulate the neural circuitry. The …
Structural biology of GABAB receptor
A Frangaj, QR Fan - Neuropharmacology, 2018 - Elsevier
Metabotropic GABA B receptor is a G protein-coupled receptor (GPCR) that mediates slow
and prolonged inhibitory neurotransmission in the brain. It functions as a constitutive …
and prolonged inhibitory neurotransmission in the brain. It functions as a constitutive …
Looking for Novelty in an “Old” Receptor: Recent Advances Toward Our Understanding of GABAARs and Their Implications in Receptor Pharmacology
Diverse populations of GABAA receptors (GABAARs) throughout the brain mediate fast
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …
Molecular diversity, trafficking and subcellular localization of GABAB receptors
GABAB receptors are the G-protein coupled receptors for the main inhibitory
neurotransmitter in the brain, γ-aminobutyric acid (GABA). While native studies predicted …
neurotransmitter in the brain, γ-aminobutyric acid (GABA). While native studies predicted …
γ-Aminobutyric acidB receptors: first of the functional metabotropic heterodimers
NG Bowery, SJ Enna - Journal of Pharmacology and Experimental …, 2000 - ASPET
Activation of the metabotropic γ-aminobutyric acidB (GABAB) receptor increases K+
conductance and decreases Ca2+ channel activity in neuronal membranes. Studies with a …
conductance and decreases Ca2+ channel activity in neuronal membranes. Studies with a …
Direct structural insights into GABAA receptor pharmacology
GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …
neuronal inhibition in the brain. In addition to their important physiological roles, they are …
Benzodiazepine Modulation of GABAA Receptors: A Mechanistic Perspective
MP Goldschen-Ohm - Biomolecules, 2022 - mdpi.com
Benzodiazepines (BZDs) are a class of widely prescribed psychotropic drugs that target
GABAA receptors (GABAARs) to tune inhibitory synaptic signaling throughout the central …
GABAA receptors (GABAARs) to tune inhibitory synaptic signaling throughout the central …
GABAB receptors: physiological functions and mechanisms of diversity
GABA B receptors are the G-protein-coupled receptors (GPCRs) for γ-aminobutyric acid
(GABA), the main inhibitory neurotransmitter in the central nervous system. GABA B …
(GABA), the main inhibitory neurotransmitter in the central nervous system. GABA B …
Structures of metabotropic GABAB receptor
Stimulation of the metabotropic GABAB receptor by γ-aminobutyric acid (GABA) results in
prolonged inhibition of neurotransmission, which is central to brain physiology. GABAB …
prolonged inhibition of neurotransmission, which is central to brain physiology. GABAB …