Application of mesenchymal stem cell-derived exosomes from different sources in intervertebral disc degeneration

Y Xia, R Yang, Y Hou, H Wang, Y Li, J Zhu… - … in bioengineering and …, 2022 - frontiersin.org
Intervertebral disc degeneration (IVDD) is a main cause of lower back pain, leading to
psychological and economic burdens to patients. Physical therapy only delays pain in …

Mesenchymal stem cell-derived exosomes: The new frontier for the treatment of intervertebral disc degeneration

V Tilotta, G Vadalà, L Ambrosio, F Russo, C Cicione… - Applied Sciences, 2021 - mdpi.com
Low back pain (LBP) is one of the most frequent symptoms associated with intervertebral
disc degeneration (IDD) and affects more than 80% of the population, with strong …

Nanoscale treatment of intervertebral disc degeneration: mesenchymal stem cell exosome transplantation

Y Hu, X Zhang, MQ Lin, HY Zhou… - Current Stem Cell …, 2023 - ingentaconnect.com
A common surgical disease, intervertebral disc degeneration (IVDD), is increasing at an
alarming rate in younger individuals. Repairing damaged intervertebral discs (IVDs) and …

Mesenchymal stem cell-derived exosomes as a novel strategy for the treatment of intervertebral disc degeneration

L Lu, A Xu, F Gao, C Tian, H Wang, J Zhang… - Frontiers in Cell and …, 2022 - frontiersin.org
Intervertebral disc degeneration (IVDD) has been reported to be the most prevalent
contributor to low back pain, posing a significant strain on the healthcare systems on a …

Mesenchymal stem cell-derived exosomes and intervertebral disc regeneration

B Bhujel, HE Shin, DJ Choi, I Han - International Journal of Molecular …, 2022 - mdpi.com
Intervertebral disc degeneration (IVDD) is a common cause of lower back pain (LBP), which
burdens individuals and society as a whole. IVDD occurs as a result of aging, mechanical …

[HTML][HTML] Exosomes derived from stem cells as an emerging therapeutic strategy for intervertebral disc degeneration

ZL Hu, HY Li, X Chang, YY Li, CH Liu… - World Journal of Stem …, 2020 - ncbi.nlm.nih.gov
Intervertebral disc (IVD) degenerative diseases are a common problem in the world, and
they cause substantial social and economic burdens for people. The current methods for …

Extracellular vesicles derived from stem cells in intervertebral disc degeneration

X Wu, W Sun - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Intervertebral disc degeneration (IVDD) is the leading cause of low back pain related to
degradation of cartilaginous tissues, mainly resulting from oxidative stress, cell apoptosis …

Therapeutic potential of extracellular vesicles in degenerative diseases of the intervertebral disc

N Piazza, M Dehghani, TR Gaborski… - … in Bioengineering and …, 2020 - frontiersin.org
Extracellular vesicles (EVs) are lipid membrane particles carrying proteins, lipids, DNA, and
various types of RNA that are involved in intercellular communication. EVs derived from …

Mechanism of action of mesenchymal stem cell-derived exosomes in the intervertebral disc degeneration treatment and bone repair and regeneration

W Liang, B Han, Y Hai, D Sun, P Yin - Frontiers in cell and …, 2022 - frontiersin.org
Exosomes are extracellular vesicles formed by various donor cells that regulate gene
expression and cellular function in recipient cells. Exosomes derived from mesenchymal …

Mesenchymal stem cell‐derived extracellular vesicles: immunomodulatory effects and potential applications in intervertebral disc degeneration

S Hu, H Xing, J Zhang, Z Zhu, Y Yin… - Stem Cells …, 2022 - Wiley Online Library
Intervertebral disc (IVD) degenerative disease is a common health problem worldwide.
Administration of mesenchymal stem cells (MSCs) in intervertebral disc degeneration (IVDD) …