Type 1 diabetes (T1D) develops when insulin-secreting β-cells, found in the pancreatic islets
of Langerhans, are destroyed by infiltrating T cells. How human T cells recognize β-cell …

Type 1 diabetes results from chronic autoimmune destruction of insulin-producing β-cells
within pancreatic islets. Although insulin is a critical self-antigen in animal models of …

Proinsulin is an abundant protein that is selectively expressed by pancreatic beta cells and
has been a focus for development of antigen-specific immunotherapies for type 1 diabetes …

Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many
autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are …

Type 1 diabetes (T1D) results from T cell–mediated destruction of insulin-producing β-cells.
Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified …

Preproinsulin (PPI) is presumably a crucial islet autoantigen found in patients with type 1
diabetes (T1D) but is also recognized by CD8+ T cells from healthy individuals. We …

Abstract Purpose of Review Autoimmune-mediated destruction of insulin-producing β-cells
within the pancreas results in type 1 diabetes (T1D), which is not yet preventable or curable …

Antibody response to insulin and to its precursor ProInsulin is associated with increased risk
for type 1 diabetes (T1D), though little is known about T cell reactivity to this molecule. In the …

A direct association of islet-autoreactive T cells with β cell destruction in human pancreatic
islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known …

Summary Type 1 diabetes (T1D) is caused by T cell-mediated destruction of the pancreatic
insulin-producing β cells. While the role of CD4+ T cells in the pathogenesis of T1D is …