The coordination of nutrient sensing, delivery, uptake and utilization is essential for
maintaining cellular, tissue and whole-body homeostasis. Such synchronization can be …

Exercise represents a major challenge to whole-body homeostasis provoking widespread
perturbations in numerous cells, tissues, and organs that are caused by or are a response to …

Exercise represents a major challenge to whole-body homeostasis. To meet this challenge,
myriad acute and adaptive responses take place at multiple cellular and systemic levels …

The maintenance of normal blood glucose levels at rest and during exercise is critical. The
maintenance of blood glucose homeostasis depends on the coordination and integration of …

Humans and other species adapt dynamically to changes in daily physical activity,
maintaining total energy expenditure within a narrow range. Chronic exercise thus …

For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …

Skeletal muscle extracts glucose from the blood to maintain demand for carbohydrates as an
energy source during exercise. Such uptake involves complex molecular signalling …

The application of molecular techniques to exercise biology has provided novel insight into
the complexity and breadth of intracellular signaling networks involved in response to …

As the single largest organ in the body, the skeletal muscle is the major site of insulin-
stimulated glucose uptake in the postprandial state. Skeletal muscles provide the …

Multidirectional interactions between metabolic organs in the periphery and the central
nervous system have evolved concomitantly with multicellular organisms to maintain whole …