Abstract Vitamin B12 (cobalamin, Cbl) is required as a cofactor by two human enzymes, 5‐
methyltetrahydrofolate‐homocysteine methyltransferase (MTR) and methylmalonyl‐CoA …

Defects in the MMACHC gene represent the most common disorder of cobalamin (Cbl)
metabolism, affecting synthesis of the enzyme cofactors adenosyl-Cbl and methyl-Cbl. The …

Conversion of vitamin B 12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and
adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial …

The reactivity of the cobalt-carbon bond in cobalamins is the key to their chemical versatility,
supporting both methyl transfer and isomerization reactions. During evolution of higher …

In mammals, B 12 (or cobalamin) is an essential cofactor required by methionine synthase
and methylmalonyl-CoA mutase. A complex intracellular pathway supports the assimilation …

Human CblC catalyzes the elimination of the upper axial ligand in cobalamin or B 12
derivatives entering the cell from circulation. This processing step is critical for assimilation …

In humans, cobalamin or vitamin B 12 is delivered to two target enzymes via a complex
intracellular trafficking pathway comprising transporters and chaperones. CblC (or …

An early step in the intracellular processing of vitamin B 12 involves CblC, which exhibits
dual reactivity, catalyzing the reductive decyanation of cyanocobalamin (vitamin B 12), and …

Conspectus Metals are partners for an estimated one-third of the proteome and vary in
complexity from mononuclear centers to organometallic cofactors. Vitamin B12 or cobalamin …

Vitamin B 12 (cobalamin (Cbl)), in the cofactor forms methyl-Cbl and adenosyl-Cbl, is
required for the function of the essential enzymes methionine synthase and methylmalonyl …