The immune system protects the body against harm by inducing inflammation. During the
immune response, cells of the immune system get activated, divided and differentiated in …

Inflammation represents the driving feature of many diseases, including atherosclerosis,
cancer, autoimmunity and infections. It is now established that metabolic processes shape a …

Cholesterol is a multifaceted metabolite that is known to modulate processes in cancer,
atherosclerosis, and autoimmunity. A common denominator between these diseases …

Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity
and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is …

There are thousands of lipid species existing in cells, which belong to eight different
categories. Lipids are the essential building blocks of cells. Recent studies have started to …

Four decades ago, it was observed that stimulation of T cells induces rapid changes in
cellular cholesterol that are required before proliferation can commence. Investigators …

Immune cell plasticity has extensive implications in the pathogenesis and resolution of
metabolic disorders, cancers, autoimmune diseases and chronic inflammatory disorders …

Cholesterol is a vital lipid and performs diverse functions on a whole body and cellular level.
However, excess cellular cholesterol is toxic, and thus, elegant mechanisms have evolved to …

Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse
roles in the control of cellular processes that go beyond the control of cholesterol …

Cholesterol has typically been considered an exogenous, disease-related factor in
immunity; however, recent literature suggests that a paradigm shift is in order. Sterols are …