ABL1 tyrosine-kinase inhibitors (TKI) are front-line therapy for chronic myelogenous
leukaemia and are among the best-known examples of targeted cancer therapeutics …

Tyrosine kinase receptors are one of the main targets in cancer therapy. They play an
essential role in the modulation of growth factor signaling and thereby inducing cell …

Stimulated Raman scattering (SRS) microscopy represents a powerful method for imaging
label-free drug distribution with high resolution. SRS was applied to image label-free …

Targeted cancer therapies block cancer growth and spread using small molecules. Many
molecular targets for an epidermal growth factor receptor (EGFR) selectively compete with …

Sensitive and specific visualization of small biomolecules in living systems is highly
challenging. We report stimulated Raman-scattering imaging of alkyne tags as a general …

Predictions about the cellular efficacy of drugs tested in vitro are usually based on the
measured responses of a few proteins or signal transduction pathways. However, cellular …

Alkyne functional groups have Raman signatures in a region (1800 cm− 1 to 2800 cm− 1)
that is free from interference from cell components, known as the “silent region”, and alkyne …

Alkyne has a unique Raman band that does not overlap with Raman scattering from any
endogenous molecule in live cells. Here, we show that alkyne-tag Raman imaging (ATRI) is …

Alkynes can be metabolically incorporated into biomolecules including nucleic acids,
proteins, lipids, and glycans. In addition to the clickable chemical reactivity, alkynes possess …

Non-invasively probing metabolites within single live cells is highly desired but challenging.
Here we utilize Raman spectro-microscopy for spatial mapping of metabolites within single …