[HTML][HTML] The role of apelin in cardiovascular diseases, obesity and cancer

MB Wysocka, K Pietraszek-Gremplewicz… - Frontiers in …, 2018 - frontiersin.org
Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …

Apelin and its receptor APJ in cardiovascular diseases

XH Yu, ZB Tang, LJ Liu, H Qian, SL Tang, DW Zhang… - Clinica Chimica …, 2014 - Elsevier
Apelin is an adipokine that has been identified as an endogenous ligand for the orphan
receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular …

The therapeutic potentials of apelin in obesity-associated diseases

I Castan-Laurell, C Dray, P Valet - Molecular and Cellular Endocrinology, 2021 - Elsevier
Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its
receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has …

Apelin, diabetes, and obesity

I Castan-Laurell, C Dray, C Attané, T Duparc, C Knauf… - Endocrine, 2011 - Springer
Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several
active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated …

[HTML][HTML] Expanding role for the apelin/APJ system in physiopathology

C Carpéné, C Dray, C Attané, P Valet… - Journal of physiology …, 2007 - ncbi.nlm.nih.gov
Apelin is a bioactive peptide known as the ligand of the G protein-coupled receptor APJ.
Diverse active apelin peptides exist under the form of 13, 17 or 36 amino acids, originated …

[HTML][HTML] The role of apelin–APJ system in diabetes and obesity

C Li, H Cheng, BK Adhikari, S Wang, N Yang… - Frontiers in …, 2022 - frontiersin.org
Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the
world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts …

Apelin in disease

H Antushevich, M Wójcik - Clinica chimica acta, 2018 - Elsevier
Apelin, a regulatory peptide, is a ligand of the APJ receptor that belongs to the G protein-
coupled receptor family. Apelin and APJ are widely distributed in the body and play potential …

[PDF][PDF] The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

AM O'Carroll, SJ Lolait, LE Harris, GR Pope - J Endocrinol, 2013 - academia.edu
The apelin receptor (APJ; gene symbol APLNR) is a member of the G protein-coupled
receptor gene family. Neural gene expression patterns of APJ, and its cognate ligand apelin …

[HTML][HTML] Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases

JC Zhong, ZZ Zhang, W Wang, SMK McKinnie… - … et Biophysica Acta (BBA …, 2017 - Elsevier
The apelin/apelin receptor system is widely distributed and has a dominant role in
cardiovascular homeostasis and disease. The apelin gene is X-linked and is synthesized as …

[HTML][HTML] The apelinergic system: the role played in human physiology and pathology and potential therapeutic applications

R Ladeiras-Lopes, J Ferreira-Martins… - Arquivos brasileiros de …, 2008 - SciELO Brasil
Apelin is a recently discovered peptide, identified as an endogenous ligand of receptor APJ.
Apelin and receptor APJ are expressed in a wide variety of tissues including heart, brain …