Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …

Genomes are more than linear sequences. In vivo they exist as elaborate physical
structures, and their functional properties are strongly determined by their cellular …

Genomes have complex three-dimensional structures. High-resolution population-based
biochemical studies over the last decade have painted a mostly static picture of the genome …

The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

Genomes are organized into complex higher-order structures by folding of the DNA into
chromatin fibers, chromosome domains, and ultimately chromosomes. The higher-order …

An expansive functionality and complexity has been ascribed to the majority of the human
genome that was unanticipated at the outset of the draft sequence and assembly a decade …

Although genomes are defined by their sequence, the linear arrangement of nucleotides is
only their most basic feature. A fundamental property of genomes is their topological …

Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …

BACKGROUND The eukaryotic genome is hierarchically organized in the cell nucleus into
DNA loops, chromatin domains, compartments, and, ultimately, chromosomes. Many of the …

The link between genomic structure and biological function is yet to be consolidated, it is,
however, clear that physical manipulation of the genome, driven by the activity of a variety of …