Brown adipocyte glucose metabolism: a heated subject

MK Hankir, M Klingenspor - EMBO reports, 2018 - embopress.org
The energy expending and glucose sink properties of brown adipose tissue (BAT) make it
an attractive target for new obesity and diabetes treatments. Despite decades of research …

Brown adipose tissue—a translational perspective

AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Brown fat fuel utilization and thermogenesis

KL Townsend, YH Tseng - Trends in Endocrinology & Metabolism, 2014 - cell.com
Brown adipose tissue (BAT) dissipates energy as heat to maintain optimal thermogenesis
and to contribute to energy expenditure in rodents and possibly humans. The energetic …

[HTML][HTML] Substrate utilization by brown adipose tissue: what's hot and what's not?

BT McNeill, NM Morton, RH Stimson - Frontiers in endocrinology, 2020 - frontiersin.org
Our understanding of brown adipose tissue (BAT) function in humans has increased rapidly
over the past 10 years. This is predominantly due to the development of powerful non …

Neuronal control of brown fat activity

S Kooijman, JK van den Heuvel… - Trends in Endocrinology & …, 2015 - cell.com
Brown adipose tissue (BAT) activation reduces body fat and metabolic disorders by the
enhanced combustion of lipids and glucose into heat. The thermogenic activity of brown …

Using brown adipose tissue to treat obesity–the central issue

AJ Whittle, M López, A Vidal-Puig - Trends in molecular medicine, 2011 - cell.com
Current therapeutic strategies are proving inadequate to deal with growing obesity rates
because of the inherent resistance of the human body to weight loss. The activation of …

[HTML][HTML] Mechanisms of impaired brown adipose tissue recruitment in obesity

M Alcalá, M Calderon-Dominguez, D Serra… - Frontiers in …, 2019 - frontiersin.org
Brown adipose tissue (BAT) dissipates energy to produce heat. Thus, it has the potential to
regulate body temperature by thermogenesis. For the last decade, BAT has been in the …

[HTML][HTML] Brown adipose tissue heterogeneity, energy metabolism, and beyond

AB Shinde, A Song, QA Wang - Frontiers in endocrinology, 2021 - frontiersin.org
Brown adipocyte in brown adipose tissue (BAT) specializes in expending energy through
non-shivering thermogenesis, a process that produces heat either by uncoupling protein 1 …

[HTML][HTML] Studying Brown Adipose Tissue in a Human in vitro Context

I Samuelson, A Vidal-Puig - Frontiers in endocrinology, 2020 - frontiersin.org
New treatments for obesity and associated metabolic disease are increasingly warranted
with the growth of the obesity pandemic. Brown adipose tissue (BAT) may represent a …

The evolving view of thermogenic adipocytes—ontogeny, niche and function

F Shamsi, CH Wang, YH Tseng - Nature Reviews Endocrinology, 2021 - nature.com
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …