Epileptic seizures typically result in delayed neuronal loss secondary to the initial damage
and an up-regulation in connexin43 (Cx43). This study investigated the role of Cx43 gap …

Despite much research, there remains controversy over the role of gap junctions in seizure
processes. Many studies report anticonvulsant effects of gap junction blockade, but …

Gap junctions within the cerebral cortex may facilitate cortical seizure formation by their
ability to synchronize electrical activity. To investigate this, one option is to compare wild …

Objective Understanding the molecular and cellular mechanisms underlying
epileptogenesis yields new insights into potential therapies that may ultimately prevent …

Gap junctions are cytoplasmic channels connecting adjacent cells and mediating their
electrical and metabolic coupling. Different cell types in the CNS express various gap …

Gap junctions (gjs) are increasingly recognized as playing a significant role in seizures. We
demonstrate that different types of gap junctional blocking agents reduce the duration of …

Glia play an under-recognized role in epilepsy. This review examines the involvement of
glial connexins (Cxs) and pannexins (Panxs), proteins which form gap junctions and …

The expression of mRNA for connexin 43, a gap junction protein putatively found in
astrocytes, is studied in two experimental models of epilepsy: the electrically kindled rat and …

Following brain injury, and during the process of neurodegeneration, a reactive astrocytic
proliferation occurs. This is accompanied by an increase in the synthesis of neuropeptides …

Objective: Large-scale synchronous firing of neurons during seizures is modulated by
electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 …