Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion
JJ Yoon, CR Green, SJ O'Carroll, LFB Nicholson - Epilepsy research, 2010 - Elsevier
Epileptic seizures typically result in delayed neuronal loss secondary to the initial damage
and an up-regulation in connexin43 (Cx43). This study investigated the role of Cx43 gap …
and an up-regulation in connexin43 (Cx43). This study investigated the role of Cx43 gap …
Connexin36 Gap Junction Blockade Is Ineffective at Reducing Seizure‐Like Event Activity in Neocortical Mouse Slices
Despite much research, there remains controversy over the role of gap junctions in seizure
processes. Many studies report anticonvulsant effects of gap junction blockade, but …
processes. Many studies report anticonvulsant effects of gap junction blockade, but …
GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity
Gap junctions within the cerebral cortex may facilitate cortical seizure formation by their
ability to synchronize electrical activity. To investigate this, one option is to compare wild …
ability to synchronize electrical activity. To investigate this, one option is to compare wild …
Expression of connexin 30 and connexin 32 in hippocampus of rat during epileptogenesis in a kindling model of epilepsy
Objective Understanding the molecular and cellular mechanisms underlying
epileptogenesis yields new insights into potential therapies that may ultimately prevent …
epileptogenesis yields new insights into potential therapies that may ultimately prevent …
Connexin 43 mimetic peptides inhibit spontaneous epileptiform activity in organotypic hippocampal slice cultures
M Samoilova, K Wentlandt, Y Adamchik… - Experimental …, 2008 - Elsevier
Gap junctions are cytoplasmic channels connecting adjacent cells and mediating their
electrical and metabolic coupling. Different cell types in the CNS express various gap …
electrical and metabolic coupling. Different cell types in the CNS express various gap …
Anticonvulsant actions of gap junctional blockers in an in vitro seizure model
SS Jahromi, K Wentlandt, S Piran… - Journal of …, 2002 - journals.physiology.org
Gap junctions (gjs) are increasingly recognized as playing a significant role in seizures. We
demonstrate that different types of gap junctional blocking agents reduce the duration of …
demonstrate that different types of gap junctional blocking agents reduce the duration of …
Curious and contradictory roles of glial connexins and pannexins in epilepsy
PL Carlen - Brain research, 2012 - Elsevier
Glia play an under-recognized role in epilepsy. This review examines the involvement of
glial connexins (Cxs) and pannexins (Panxs), proteins which form gap junctions and …
glial connexins (Cxs) and pannexins (Panxs), proteins which form gap junctions and …
Connexin 43 mRNA expression in two experimental models of epilepsy
K Elisevich, SA Rempel, B Smith, N Allar - Molecular and chemical …, 1997 - Springer
The expression of mRNA for connexin 43, a gap junction protein putatively found in
astrocytes, is studied in two experimental models of epilepsy: the electrically kindled rat and …
astrocytes, is studied in two experimental models of epilepsy: the electrically kindled rat and …
Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy
CG Fonseca, CR Green, LFB Nicholson - Brain research, 2002 - Elsevier
Following brain injury, and during the process of neurodegeneration, a reactive astrocytic
proliferation occurs. This is accompanied by an increase in the synthesis of neuropeptides …
proliferation occurs. This is accompanied by an increase in the synthesis of neuropeptides …
Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors
GM Jacobson, LJ Voss, SM Melin, JP Mason… - Brain research, 2010 - Elsevier
Objective: Large-scale synchronous firing of neurons during seizures is modulated by
electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 …
electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 …