Neuroendocrine neoplasms (NENs) encompass tumors arising from neuroendocrine cells in
various organs, including the gastrointestinal tract, pancreas, adrenal gland, and …

Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal
malignancies and is not a clinically homogeneous disease, but subsets of patients with …

Pancreatic ductal adenocarcinoma (PDAC) is the most common and among the deadliest of
pancreatic cancers. Its 5-year survival is only∼ 8%. Pancreatic cancers are a …

Background Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-
related mortality in the world; however, the molecular mechanisms leading to hepatocyte …

Context SDHB mutations are found in an increasing number of neoplasms, most notably in
paragangliomas and pheochromocytomas (PPGLs). SDHB-PPGLs are slow-growing …

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of
rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic …

It has recently been reported that CDH13 expression is silenced by aberrant methylation of
the promoter region in several cancers. We examined the methylation status of the CDH13 …

DNA methylation is a crucial epigenetic mechanism for gene expression regulation and cell
differentiation. Furthermore, it was found to play a major role in multiple pathological …

This study aimed to profile the methylation statuses of CDH1/E-cadherin and five CpG island
methylator phenotype (CIMP)-associated genes (p16, hMLH1, MINT1, MINT2, and MINT31) …

Colorectal poorly differentiated neuroendocrine carcinomas (NECs) and mixed
adenoneuroendocrine carcinomas (MANECs) are well-recognized entities generally known …