[HTML][HTML] Aquaporins: more than functional monomers in a tetrameric arrangement
M Ozu, L Galizia, C Acuña, G Amodeo - Cells, 2018 - mdpi.com
Aquaporins (AQPs) function as tetrameric structures in which each monomer has its own
permeable pathway. The combination of structural biology, molecular dynamics simulations …
permeable pathway. The combination of structural biology, molecular dynamics simulations …
The hidden intricacies of aquaporins: Remarkable details in a common structural scaffold
Evolution turned aquaporins (AQPs) into the most efficient facilitators of passive water flow
through cell membranes at no expense of solute discrimination. In spite of a plethora of …
through cell membranes at no expense of solute discrimination. In spite of a plethora of …
[HTML][HTML] Structural determinants of oligomerization of the aquaporin-4 channel
The aquaporin (AQP) family of integral membrane protein channels mediate cellular water
and solute flow. Although qualitative and quantitative differences in channel permeability …
and solute flow. Although qualitative and quantitative differences in channel permeability …
[HTML][HTML] Molecular mechanisms of conduction and selectivity in aquaporin water channels
Y Wang, E Tajkhorshid - The Journal of nutrition, 2007 - Elsevier
Aquaporins (AQP) are a family of membrane channels primarily responsible for conducting
water across cellular membranes. The availability of a large body of high resolution …
water across cellular membranes. The availability of a large body of high resolution …
[HTML][HTML] Dynamic and energetic mechanisms for the distinct permeation rate in AQP1 and AQP0
Despite sharing overall sequence and structural similarities, water channel aquaporin 0
(AQP0) transports water more slowly than other aquaporins. Using molecular dynamics …
(AQP0) transports water more slowly than other aquaporins. Using molecular dynamics …
Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology
Aquaporins (AQPs) are multifunctional transmembrane channel proteins permeable to water
and an expanding array of solutes. AQP-mediated ion channel activity was first observed …
and an expanding array of solutes. AQP-mediated ion channel activity was first observed …
Structural insights into aquaporin selectivity and regulation
S Kreida, S Törnroth-Horsefield - Current opinion in structural biology, 2015 - Elsevier
Highlights•Structural studies of aquaporins give new insights into selectivity and regulation.•
Subångström resolution structure yeast Aqy1 revises the proton exclusion mechanism.•A …
Subångström resolution structure yeast Aqy1 revises the proton exclusion mechanism.•A …
Water transport in AQP0 aquaporin: molecular dynamics studies
BG Han, AB Guliaev, PJ Walian, BK Jap - Journal of molecular biology, 2006 - Elsevier
A double lipid bilayer structure containing opposing tetramers of AQP0 aquaporin, in contact
through extracellular face loop regions, was recently modeled using an intermediate …
through extracellular face loop regions, was recently modeled using an intermediate …
Dynamics and energetics of permeation through aquaporins. What do we learn from molecular dynamics simulations?
Aquaporins (AQPs) are a family of integral membrane proteins, which facilitate the rapid and
yet highly selective flux of water and other small solutes across biological membranes …
yet highly selective flux of water and other small solutes across biological membranes …