Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Metformin is now established as a first-line antidiabetic therapy for the management of type
2 diabetes. Its early use in treatment algorithms is supported by lack of weight gain, low risk …

Metformin, a biguanide, has been available in the US for the treatment of type 2 diabetes
mellitus for nearly 8 years. Over this period of time, it has become the most widely prescribed …

Metformin is a biguanide that has been used worldwide for the treatment of type 2 diabetes
for the past 4 decades. It improves glycemic control by enhancing insulin sensitivity in liver …

The management of T2DM requires aggressive treatment to achieve glycemic and
cardiovascular risk factor goals. In this setting, metformin, an old and widely accepted first …

Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-
lowering agent to manage type 2 diabetes. Its history is linked to Galega officinalis (also …

Management guidelines continue to identify metformin as initial pharmacologic antidiabetic
therapy of choice for people with type 2 diabetes without contraindications, despite recent …

Metformin is one of the most popular oral glucose-lowering medications, widely considered
to be the optimal initial therapy for patients with type 2 diabetes mellitus. Interestingly, there …

Background: The usefulness of metformin as an oral antidiabetic agent is widely accepted.
However, several other classes of oral antidiabetic agents have been recently introduced …

Insulin resistance, defined as the inability of insulin to exert a normal biological action at the
level of its target tissues, is one of the principal patho-genetic defects of type 2 diabetes …