The objective of this study was to investigate the effect of Trichostatin A (TSA) treatment on
the development of intra-and inter-species cloned embryos. The cattle (Bos taurus) …

This study was carried out to investigate the effect of trichostatin A (TSA) treatment on
interspecies cloned gaur (Bos gaurus) embryos development and implantation rate after …

It has been reported that 5 or 50 nM trichostatin A (TSA) treatment after somatic cell nuclear
transfer (NT) improves the success rate of mouse cloning (Kishigami et al. 2006 Biochem …

Introduction and aims Although, it has been success in the generation of animal clones from
somatic cells in various animal species, the information related to nuclear reprogramming of …

We investigated the effects of exposure time and concentration of trichostatin A (TSA) on in
vitro development and quality of bovine SCNT embryos. At multiple time points, the relative …

Accumulating evidence suggests that trichostatin A (TSA), a histone deacetylase inhibitor,
can increase the success rate of somatic cloning. The objective of this study was to …

Transgenes integrated into mammalian cells are silenced rapidly. This phenomenon
correlates with repressed chromatin structure marked by histone hypoacetylation. This study …

Although cloning by somatic cell nuclear transfer (SCNT) has been achieved in various
mammalian species, its efficiency has been very low (Han et al. 2003 Theriogenology 59, 33 …

Developmental potential of cloned embryos is related closely to epigenetic modification of
somatic cell genome. The present study was to investigate the effects of applying histone …

Both preimplantation and full-term development of mouse somatic cell nuclear transfer
(SCNT) embryos are significantly enhanced by treatment with trichostatin A (TSA), an …