A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes
A well-balanced human diet includes a significant intake of non-starch polysaccharides,
collectively termed 'dietary fibre', from the cell walls of diverse fruits and vegetables. Owing …
collectively termed 'dietary fibre', from the cell walls of diverse fruits and vegetables. Owing …
Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans
Changing food preferences brought about by westernization that have deleterious health
effects,—combined with myriad forces that are contributing to increased food insecurity—are …
effects,—combined with myriad forces that are contributing to increased food insecurity—are …
Complex pectin metabolism by gut bacteria reveals novel catalytic functions
The metabolism of carbohydrate polymers drives microbial diversity in the human gut
microbiota. It is unclear, however, whether bacterial consortia or single organisms are …
microbiota. It is unclear, however, whether bacterial consortia or single organisms are …
A Bacteroidetes locus dedicated to fungal 1, 6-β-glucan degradation: unique substrate conformation drives specificity of the key endo-1, 6-β-glucanase
Glycans are major nutrients available to the human gut microbiota. The Bacteroides are
generalist glycan degraders, and this function is mediated largely by polysaccharide …
generalist glycan degraders, and this function is mediated largely by polysaccharide …
Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut Bacteroides
INTRODUCTION Relatively little is known about the genetic factors that allow members of
the human gut microbiota to occupy their niches. Identification of these factors is important …
the human gut microbiota to occupy their niches. Identification of these factors is important …
Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides
The largest living rodent, capybara, can efficiently depolymerize and utilize lignocellulosic
biomass through microbial symbiotic mechanisms yet elusive. Herein, we elucidate the …
biomass through microbial symbiotic mechanisms yet elusive. Herein, we elucidate the …
Glycan foraging in vivo by an intestine-adapted bacterial symbiont
Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and
colonized for 10 days with an organism also found in human guts, Bacteroides …
colonized for 10 days with an organism also found in human guts, Bacteroides …
Synergy between Cell Surface Glycosidases and Glycan-Binding Proteins Dictates the Utilization of Specific Beta(1,3)-Glucans by Human Gut Bacteroides
G Déjean, K Tamura, A Cabrera, N Jain, NA Pudlo… - MBio, 2020 - Am Soc Microbiol
The human gut microbiota (HGM) has far-reaching impacts on human health and nutrition,
which are fueled primarily by the metabolism of otherwise indigestible complex …
which are fueled primarily by the metabolism of otherwise indigestible complex …
Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota
JH Hehemann, G Correc, T Barbeyron, W Helbert… - Nature, 2010 - nature.com
Gut microbes supply the human body with energy from dietary polysaccharides through
carbohydrate active enzymes, or CAZymes, which are absent in the human genome. These …
carbohydrate active enzymes, or CAZymes, which are absent in the human genome. These …
Configured for the human gut microbiota: molecular mechanisms of dietary β-glucan utilization
B Golisch, Z Lei, K Tamura, H Brumer - ACS Chemical Biology, 2021 - ACS Publications
The β-glucans are a disparate group of structurally diverse polysaccharides, whose
members are widespread in human diets as components of the cell walls of plants, algae …
members are widespread in human diets as components of the cell walls of plants, algae …