Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity

S Srivastav, S Neupane, S Bhurtel, N Katila… - The Journal of …, 2019 - Elsevier
Microbiota in the gut affect brain physiology via various pathways, and dysbiosis seems to
play a role in the pathogenesis of Parkinson's disease (PD). Probiotics showed pleiotropic …

Neuroprotective Effects of Bifidobacterium breve CCFM1067 in MPTP-Induced Mouse Models of Parkinson's Disease

T Li, C Chu, L Yu, Q Zhai, S Wang, J Zhao, H Zhang… - Nutrients, 2022 - mdpi.com
There is mounting evidence that the microbiota–gut–brain axis (MGBA) is critical in the
pathogenesis and progression of Parkinson's disease (PD), suggesting that probiotic …

Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson's disease via gut microbiota-GLP-1 pathway

J Sun, H Li, Y Jin, J Yu, S Mao, KP Su, Z Ling… - Brain, behavior, and …, 2021 - Elsevier
A connection between gut microbiota and Parkinson's disease (PD) indicates that dysbiosis
of the gut microbiota might represent a risk factor for PD. Microbiota-targeted interventions …

Probiotics for Parkinson's disease: Current evidence and future directions

AH Tan, JW Hor, CW Chong, SY Lim - JGH Open, 2021 - Wiley Online Library
The gut–brain axis is a hot topic in Parkinson's disease (PD). It has been postulated that gut
pathogens and dysbiosis can contribute to peripheral inflammatory states or trigger …

Neurogenic and anti-inflammatory effects of probiotics in Parkinson's disease: A systematic review of preclinical and clinical evidence

V Leta, KR Chaudhuri, O Milner, G Chung-Faye… - Brain, Behavior, and …, 2021 - Elsevier
There is increasing evidence highlighting the potential role of the gut-brain axis in the
pathogenesis of Parkinson's disease (PD) and on the use of probiotics as a therapeutic …

Neuroprotective effects of sodium butyrate by restoring gut microbiota and inhibiting TLR4 signaling in mice with MPTP-induced Parkinson's disease

TT Guo, Z Zhang, Y Sun, RY Zhu, FX Wang, LJ Ma… - Nutrients, 2023 - mdpi.com
Parkinson's disease (PD) is a prevalent type of neurodegenerative disease. There is
mounting evidence that the gut microbiota is involved in the pathogenesis of PD. Sodium …

Polymannuronic acid prebiotic plus Lacticaseibacillus rhamnosus GG probiotic as a novel synbiotic promoted their separate neuroprotection against Parkinson's …

X Liu, ZR Du, X Wang, XR Sun, Q Zhao, F Zhao… - Food Research …, 2022 - Elsevier
Gut microbiota (GM) dysbiosis plays key roles in aggravating Parkinson's disease (PD) and
discovery of agents targeting GM may open new avenues for PD therapy. This study aims to …

Probiotic enhancement of antioxidant capacity and alterations of gut microbiota composition in 6-hydroxydopamin-induced parkinson's disease rats

SP Tsao, BA Nurrahma, R Kumar, CH Wu, TH Yeh… - Antioxidants, 2021 - mdpi.com
Oxidative stress plays a key role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD), which may be aggravated by concomitant PD-associated gut …

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling …

MF Sun, YL Zhu, ZL Zhou, XB Jia, YD Xu… - Brain, behavior, and …, 2018 - Elsevier
Parkinson's disease (PD) patients display alterations in gut microbiota composition.
However, mechanism between gut microbial dysbiosis and pathogenesis of PD remains …

[HTML][HTML] Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment

S Salim, F Ahmad, A Banu, F Mohammad - Journal of Advanced Research, 2023 - Elsevier
Background Parkinson's disease (PD) is a disease of⍺-synuclein aggregation-mediated
dopaminergic neuronal loss in the substantia nigra pars compacta, which leads to motor and …