Phenobarbital is a central nervous system depressant that also indirectly activates nuclear
receptor constitutive active androstane receptor (CAR), which promotes drug and energy …

The constitutive androstane receptor (CAR), a member of the nuclear receptor superfamily,
is a well-known xenosensor that regulates hepatic drug metabolism and detoxification. CAR …

The nuclear receptor constitutive active/androstane receptor (CAR) is sequestered in the
cytoplasm of liver cells before its activation by therapeutic drugs and xenobiotics such as …

The constitutive androstane receptor (CAR) is initially defined as a xenobiotic nuclear
receptor that protects the liver from injury. Detoxification of damaging chemicals is achieved …

The constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor
gamma coactivator-1α (PGC1α) are master regulators of drug metabolism and …

Phenobarbital (PB) administration is known to trigger pleiotropic responses, including liver
hypertrophy, tumor promotion, and induction of genes encoding drug-metabolizing …

Compared with its rodent orthologs, little is known about the chemical specificity of human
constitutive androstane receptor (hCAR) and its regulation of hepatic enzyme expression …

Objective Accumulating evidence suggests that activation of mouse constitutive androstane
receptor (mCAR) alleviates type 2 diabetes and obesity by inhibiting hepatic …

Metformin is currently the most widely used drug for the treatment of type 2 diabetes.
Mechanistically, metformin interacts with many protein kinases and transcription factors that …

CAR (constitutive androstane receptor) is a nuclear receptor that regulates the transcription
of target genes, including CYP (cytochrome P450) 2B and 3A. The transactivation by CAR is …