The last decade has seen an explosion in knowledge of the molecular basis and treatment
of cancer. The molecular events that define the lethal phenotype of various cancers—the …

After a quarter century of rapid advances, cancer research has generated a rich and
complex body of knowledge, revealing cancer to be a disease involving dynamic changes in …

Drawn from the content of the new Ninth Edition of Cancer: Principles and Practice of
Oncology, this unique publication brings together the basic scientific information on the …

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date
information and insight into the genetic basis of cancer and the mechanisms involved in …

This article provides an overview of the genes and cellular processes that have emerged
recently as new key factors in tumorigenesis. We review these in the context of three broad …

Several observations have led us to a new hypothesis for cancer mechanism. First, that
cancer appears only on those multicellular organisms with complicated wound-healing …

In the last decade, basic cancer research has produced remarkable advances in our
understanding of cancer biology and cancer genetics. Among the most important of these …

Cancer is a major human health problem worldwide and is the second leading cause of
death in the United States (1). Over the past 30 years, significant progress has been …

Cancer is caused by genetic changes that activate oncogenes or inactivate tumor
suppressor genes. The repair or inactivation of mutant genes may be effective in the …

Drug resistance, to date, has primarily been attributed to increased drug export or
detoxification mechanisms. Despite correlations between drug export and drug resistance, it …