MCL-1 is the prosurvival member of the Bcl-2 family. It prevents the induction of
mitochondria-dependent apoptosis. The molecular mechanisms dictating the host cell …

Accumulating evidence suggests that Mcl-1 plays a critical pro-survival role in the
development and maintenance of both normal and malignant tissues. Regulation of Mcl-1 …

Resistance to apoptosis is a common challenge in human malignancies contributing to both
progress of cancer and resistance to conventional therapeutics. Abnormalities in a variety of …

Infection of mammalian cells with viruses often induces apoptosis. How the recognition of
viruses leads to apoptosis of the infected cell and which host cell factors regulate this cell …

Apoptosis is an evolutionarily conserved form of programed cell death (PCD) that has a vital
effect on early embryonic development, tissue homeostasis and clearance of damaged cells …

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control,
promoting cell survival by interfering at an early stage in a cascade of events leading to …

Background: Myeloid cell leukemia-1 (Mcl-1) plays an important role in the clearance of
Mycobacterium tuberculosis (MTB) infection. It has the effect of anti-apoptosis, protecting …

The ability to regulate the survival and death of a cell is paramount throughout the lifespan of
a multicellular organism. Apoptosis, a main physiological form of programmed cell death, is …

As an important regulator of apoptosis, Mcl-1 protein, a member of the Bcl-2 family,
represents an attractive target for cancer treatment. The recent development of novel small …

Theiler's murine encephalomyelitis virus (TMEV) results in a persistent central nervous
system infection (CNS) and immune-mediated demyelination in mice. TMEV largely persists …