The emergence and increasing prevalence of bacterial strains that are resistant to available
antibiotics demand the discovery of new therapeutic approaches. Targeting bacterial …

The rapid evolution and dissemination of antibiotic resistance among bacterial pathogens
are outpacing the development of new antibiotics, but antivirulence agents provide an …

Bacterial resistance to antibiotics is an issue that has led to the search for new antibacterial
approaches. Drugs targeting virulence is an alternative approach to treat infections due to …

Resistance of important bacterial pathogens to common antimicrobial therapies and the
emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute …

The continued rise of antibiotic-resistant bacterial infections has motivated alternative
strategies for target discovery and treatment of infections. Antivirulence therapies function …

Targeting virulence factors has gained increasing attention as a potential approach to new
antibiotics. Small molecule inhibitors of virulence have been shown to change the course of …

Antivirulence drugs are a new type of therapeutic drug that target virulence factors,
potentially revitalising the drug-development pipeline with new targets. As antivirulence …

In April 2014, the World Health Organization announced the beginning of a post-antibiotic
era and declared antimicrobial resistance (AMR) a public health priority demanding global …

The emergence and increasing prevalence of multidrug-resistant pathogens has become a
major global healthcare problem. According to the World Health Organization if these trends …

Antibiotic resistance is one of the greatest challenges of the twenty-first century. However,
the increasing understanding of bacterial pathogenesis and intercellular communication has …