Novel drugs targeting Toll-like receptors for antiviral therapy
MC Patel, KA Shirey, LM Pletneva… - Future …, 2014 - Taylor & Francis
Toll-like receptors (TLRs) are sentinel receptors of the host innate immune system that
recognize conserved'pathogen-associated molecular patterns' of invading microbes …
recognize conserved'pathogen-associated molecular patterns' of invading microbes …
Advances in antiviral therapies targeting toll-like receptors
Introduction: Organisms have evolved a rapid and non-specific way to defend themselves
via Toll-like receptors (TLRs), which recognize specific signatures present on invading …
via Toll-like receptors (TLRs), which recognize specific signatures present on invading …
Toll-like receptors in antiviral innate immunity
SN Lester, K Li - Journal of molecular biology, 2014 - Elsevier
Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune
system, which detect conserved molecular signatures of a wide range of microbial …
system, which detect conserved molecular signatures of a wide range of microbial …
[HTML][HTML] Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines
Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-
recognition receptors. They function as sensors of invading pathogens through recognition …
recognition receptors. They function as sensors of invading pathogens through recognition …
Recent insights into the role of Toll-like receptors in viral infection
Toll-like receptors (TLRs) have a central role in innate immunity as they detect conserved
pathogen-associated molecular patterns (PAMPs) on a range of microbes, including viruses …
pathogen-associated molecular patterns (PAMPs) on a range of microbes, including viruses …
Toll-like receptors regulation of viral infection and disease
JM Thompson, A Iwasaki - Advanced drug delivery reviews, 2008 - Elsevier
In recent years, it has become increasingly evident that mammalian Toll-like receptors
(TLRs) play a critical role in determining the outcome of virus infection. TLRs have evolved …
(TLRs) play a critical role in determining the outcome of virus infection. TLRs have evolved …
Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
LAJ O'Neill - Current opinion in pharmacology, 2003 - Elsevier
Roles for Toll-like receptors (TLRs) are emerging in conditions such as sepsis syndrome,
systemic lupus erythromatosis, rheumatoid arthritis and asthma, suggesting that the …
systemic lupus erythromatosis, rheumatoid arthritis and asthma, suggesting that the …
[HTML][HTML] TLR agonists as modulators of the innate immune response and their potential as agents against infectious disease
EJ Mifsud, ACL Tan, DC Jackson - Frontiers in immunology, 2014 - frontiersin.org
Immunotherapies that can either activate or suppress innate immune responses are being
investigated as treatments against infectious diseases and the pathology they can cause …
investigated as treatments against infectious diseases and the pathology they can cause …
Prophylactic and therapeutic implications of toll‐like receptor ligands
M Hedayat, K Takeda, N Rezaei - Medicinal research reviews, 2012 - Wiley Online Library
The evolutionary conserved Toll‐like receptors (TLRs) are the first identified and best
characterized pattern recognition receptors (PRRs) which discriminate self from nonself …
characterized pattern recognition receptors (PRRs) which discriminate self from nonself …
[HTML][HTML] Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases
A Savva, T Roger - Frontiers in immunology, 2013 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors playing a fundamental role in
sensing microbial invasion and initiating innate and adaptive immune responses. TLRs are …
sensing microbial invasion and initiating innate and adaptive immune responses. TLRs are …