Osteoarthritis (OA) is characterized by cartilage degradation that is induced by inflammation.
Sterile inflammation can be caused by damage-associated molecular patterns that are …

In rheumatoid arthritis, a significant proportion of cytokine and chemokine synthesis is
attributed to innate immune mechanisms. TLR4 is a prominent innate receptor since several …

Toll‐like receptors (TLRs) are involved in mediating cell activation on stimulation with
microbial components. Our objective was to investigate the role of TLR‐2 mediated by the …

Toll-like receptors (TLRs) may contribute to the pathogenesis of chronic inflammatory
destructive diseases through the recognition of endogenous ligands produced on either …

OBJECTIVE: The objective of this study was to examine expression and regulation of Toll-
like receptor 2 (TLR2) in human articular chondrocytes. METHODS: Human articular …

Objective To examine the catabolic pathways mediated by Toll‐like receptor (TLR) ligands
in human osteoarthritic (OA) chondrocytes. Methods The presence of TLRs in OA and non …

Because inflammation in osteoarthritis (OA) is related to the Toll-like receptor 4 (TLR4)
signaling cascades, TLR4 is a reasonable target for developing therapeutics for OA. Thus …

Objectives The aim of our study was to evaluate the role of cell-membrane expressed TLRs
and the signaling molecule MyD88 in a murine model of OA induced by knee menisectomy …

Background and purpose Degenerating cartilage releases potential danger signals that
react with Toll-like receptor (TLR) type danger receptors. We investigated the presence and …

Osteoarthritis (OA) is characterized by inflammation of joints and degradation of articular
cartilage matrix. As involvement of damage-associated molecular patterns (DAMPs) in the …