Animal models of developmental motor disorders: parallels to human motor dysfunction in cerebral palsy

CF Cavarsan, MA Gorassini… - Journal of …, 2019 - journals.physiology.org
Cerebral palsy (CP) is the most common motor disability in children. Much of the previous
research on CP has focused on reducing the severity of brain injuries, whereas very few …

A battery of motor tests in a neonatal mouse model of cerebral palsy

DN Feather-Schussler, TS Ferguson - JoVE (Journal of Visualized …, 2016 - jove.com
As the sheer number of transgenic mice strains grow and rodent models of pediatric disease
increase, there is an expanding need for a comprehensive, standardized battery of neonatal …

[HTML][HTML] Sex may influence motor phenotype in a novel rodent model of cerebral palsy

BR Aravamuthan, S Gandham, AB Young… - Neurobiology of …, 2020 - Elsevier
Cerebral palsy (CP) is the most common cause of childhood motor disability, manifesting
most often as spasticity and/or dystonia. Spasticity and dystonia are often co-morbid …

Locomotion is impacted differently according to the perinatal brain injury model: Meta-analysis of preclinical studies with implications for cerebral palsy

S da Conceição Pereira, R Manhães-de-Castro… - Journal of Neuroscience …, 2021 - Elsevier
Background Different approaches to reproduce cerebral palsy (CP) in animals, contribute to
the knowledge of the pathophysiological mechanism of this disease and provide a basis for …

Can noninvasive brain stimulation measure and modulate developmental plasticity to improve function in stroke-induced cerebral palsy?

A Kirton - Seminars in pediatric neurology, 2013 - Elsevier
The permanent nature of motor deficits is a consistent cornerstone of cerebral palsy
definitions. Such pessimism is disheartening to children, families, and researchers alike and …

What are the best animal models for testing early intervention in cerebral palsy?

GJ Clowry, R Basuodan, F Chan - Frontiers in neurology, 2014 - frontiersin.org
Interventions to treat cerebral palsy should be initiated as soon as possible in order to
restore the nervous system to the correct developmental trajectory. One drawback to this …

Evidence for therapeutic intervention in the prevention of cerebral palsy: hope from animal model research

A Nguyen, EA Armstrong, JY Yager - Seminars in Pediatric Neurology, 2013 - Elsevier
Knowledge translation, as defined by the Canadian Institute of Health Research, is defined
as the exchange, synthesis, and ethically sound application of knowledge—within a …

[HTML][HTML] A critical evaluation of current concepts in cerebral palsy

JE Brandenburg, MJ Fogarty, GC Sieck - Physiology, 2019 - journals.physiology.org
Spastic cerebral palsy (CP), despite the name, is not consistently identifiable by specific
brain lesions. CP animal models focus on risk factors for development of CP, yet few …

From cerebral palsy to developmental coordination disorder: Development of preclinical rat models corresponding to recent epidemiological changes

JO Coq, M Kochmann, DC Lacerda, H Khalki… - Annals of Physical and …, 2020 - Elsevier
Cerebral palsy (CP) is a complex syndrome of various sensory, motor and cognitive deficits.
Its prevalence has recently decreased in some developed countries and its symptoms have …

Impact of neonatal asphyxia and hind limb immobilization on musculoskeletal tissues and S1 map organization: implications for cerebral palsy

JO Coq, F Strata, M Russier, FF Safadi… - Experimental …, 2008 - Elsevier
Cerebral palsy (CP) is a complex disorder of locomotion, posture and movements resulting
from pre-, peri-or postnatal damage to the developing brain. In a previous study (Strata, F …