Regulation of bacterial virulence by Csr (Rsm) systems

CA Vakulskas, AH Potts, P Babitzke… - Microbiology and …, 2015 - Am Soc Microbiol
Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …

Post‐transcriptional regulation on a global scale: form and function of Csr/Rsm systems

T Romeo, CA Vakulskas… - Environmental …, 2013 - Wiley Online Library
Originally described as a repressor of gene expression in the stationary phase of growth,
CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation …

An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa

JN Marden, MR Diaz, WG Walton… - Proceedings of the …, 2013 - National Acad Sciences
Members of the CsrA family of prokaryotic mRNA-binding proteins alter the translation
and/or stability of transcripts needed for numerous global physiological processes. The …

[HTML][HTML] Structural rearrangement in an RsmA/CsrA ortholog of Pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN

ER Morris, G Hall, C Li, S Heeb, RV Kulkarni… - Structure, 2013 - cell.com
In bacteria, the highly conserved RsmA/CsrA family of RNA-binding proteins functions as
global posttranscriptional regulators acting on mRNA translation and stability. Through …

The post-transcriptional regulator CsrA plays a central role in the adaptation of bacterial pathogens to different stages of infection in animal hosts

C Lucchetti-Miganeh, E Burrowes, C Baysse… - …, 2008 - microbiologyresearch.org
The importance of Csr post-transcriptional systems is gradually emerging; these systems
control a variety of virulence-linked physiological traits in many pathogenic bacteria. This …

Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA

A Brencic, S Lory - Molecular microbiology, 2009 - Wiley Online Library
One of the prokaryotic post‐transcriptional regulatory mechanisms involves the CsrA/RsmA
family of proteins that act by modulating translation initiation at target mRNAs. In this study …

Global regulation by CsrA and its RNA antagonists

T Romeo, P Babitzke - Microbiology spectrum, 2018 - Am Soc Microbiol
The sequence-specific RNA binding protein CsrA is employed by diverse bacteria in the
posttranscriptional regulation of gene expression. Its binding interactions with RNA have …

CsrB sRNA family: sequestration of RNA-binding regulatory proteins

P Babitzke, T Romeo - Current opinion in microbiology, 2007 - Elsevier
Noncoding regulatory RNA molecules, also known as small RNAs, participate in several
bacterial regulatory networks. The central component of the carbon storage regulator (Csr) …

Global regulation by the small RNA‐binding protein CsrA and the non‐coding RNA molecule CsrB

T Romeo - Molecular microbiology, 1998 - Wiley Online Library
Csr (carbon storage regulator) is a recently discovered global regulatory system that controls
bacterial gene expression post‐transcriptionally. Its effector is a small RNA‐binding protein …

Post-transcriptional global regulation by CsrA in bacteria

J Timmermans, L Van Melderen - Cellular and molecular life sciences, 2010 - Springer
Global regulation allows bacteria to rapidly modulate the expression of a large variety of
unrelated genes in response to environmental changes. Global regulators act at different …