Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H2O2-Induced Neuronal PC12 Cells and Prolongs the Lifespan of …

S Wu, J Miao, S Zhu, X Wu, J Shi, J Zhou, Y Xing… - Molecular …, 2024 - Springer
Despite tremendous advances in modern medicine, effective prevention or therapeutic
strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) …

Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the Akt/mTOR Signaling Pathway

K Hu, S Wu, J Xu, Y Zhang, Y Zhang, X Wu… - Journal of Agricultural …, 2024 - ACS Publications
Alzheimer's disease (AD), one of the neurodegenerative disorders, is highly correlated with
the abnormal hyperphosphorylation of Tau and aggregation of β-amyloid (Aβ). Oxidative …

Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-Deficient Caenorhabditis elegans

D Cai Shi, C Long, E Vardeman, EJ Kennelly… - Molecules, 2023 - mdpi.com
Vitamin B12 deficiency can lead to oxidative stress, which is known to be involved in
neurodegenerative diseases such as Alzheimer's disease (AD). Mogrosides are plant …

Panax Notoginseng Saponins Ameliorate Aβ‐Mediated Neurotoxicity in C. elegans through Antioxidant Activities

L Zhou, PP Huang, LL Chen… - … and Alternative Medicine, 2019 - Wiley Online Library
The deposition of amyloid beta (Aβ) is the main hallmark of Alzheimer's disease (AD) and
there is no effective drug to cure the progressive cognitive loss or memory deficits caused by …

Ginkgolide B protects against cognitive impairment in senescence-accelerated P8 mice by mitigating oxidative stress, inflammation and ferroptosis

L Shao, C Dong, D Geng, Q He, Y Shi - Biochemical and biophysical …, 2021 - Elsevier
Alzheimer's disease (AD) is a destructive neurodegenerative disease that currently has no
effective treatment option available. Ginkgolide B (GB) is a terpene lactone derivative of …

Formononetin attenuates H2O2-induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK …

M Sugimoto, R Ko, H Goshima, A Koike, M Shibano… - Neurotoxicology, 2021 - Elsevier
Formononetin is an isoflavone, found in herbs like Trifolium pratense, which executes a
variety of physiological activities including anti-neurodegenerative effect. However, the …

AD− 1 small molecule improves learning and memory function in scopolamine-induced amnesic mice model through regulation of CREB/BDNF and NF-κB/MAPK …

R Balakrishnan, JY Park, DY Cho, JY Ahn, DS Yoo… - Antioxidants, 2023 - mdpi.com
Cognitive decline and memory impairment induced by oxidative brain damage are the
critical pathological hallmarks of Alzheimer's disease (AD). Based on the potential …

Phytochemical allylguaiacol exerts a neuroprotective effect on hippocampal cells and ameliorates scopolamine-induced memory impairment in mice

HS Lim, BY Kim, YJ Kim, SJ Jeong - Behavioural Brain Research, 2018 - Elsevier
Allylguaiacol is a phytochemical occurring in various plants such as cloves, cinnamon, basil,
and nutmeg. Pharmacological effects of allylguaiacol include antimicrobial, anti …

Aureusidin ameliorates 6-OHDA-induced neurotoxicity via activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway in SH …

K Hu, S Zhu, F Wu, Y Zhang, M Li, L Yuan… - Chemico-Biological …, 2024 - Elsevier
Movement disorder Parkinson's disease (PD) is the second most common
neurodegenerative disease in the world after Alzheimer's disease, which severely affects the …

Oolonghomobisflavans exert neuroprotective activities in cultured neuronal cells and anti-aging effects in Caenorhabditis elegans

S Zhang, C Duangjan, T Tencomnao, L Wu… - Frontiers in Aging …, 2022 - frontiersin.org
Potential health benefits of tea has attracted significant scientific and public attention
worldwide. Tea polyphenols are considered as natural promising complementary …