Exploring multi-targeting chemotherapeutants with advantages over single-targeting agents
and drug combinations is of great significance in drug discovery. Herein, we employed …

While platinum-based chemotherapeutic agents have established themselves as
indispensable components of anticancer therapy, they are accompanied by a variety of side …

Theranostic anticancer agents with dual functions of diagnosis and therapy are in highly
demand for breast cancer. Herein, a triphenylphosphonium (TPP)-decorated aggregation …

Developing multifunctional platinum (IV) prodrugs via integrating bioactive pharmacophores
into one entity is an attractive strategy to ameliorate the defects of platinum (II) drugs. Herein …

Targeted anticancer prodrugs that can be controllably activated are highly desired for
personalized precision medicine in cancer therapy. Such prodrugs with unique action …

Cancer treatment requires the participation of multiple targets/pathways, and single
approach is hard to effectively curb the proliferation and metastasis of carcinoma cells. In …

Many strategies have been developed to circumvent the shortcomings of Pt (II)-based
chemotherapy, but the inherent problems still have not been effectively resolved. Here we …

Recently, artemisinin and derivatives have been revealed to possess encouraging antitumor
activity. Herein, we integrated the antitumor advantages of artesunate and platinum drugs to …

HER2‐positive breast cancer is an aggressive subtype that typically responds poorly to
standard chemotherapy. To design an anticancer drug selective for HER2‐expressing …

DNA damage response plays a key role not only in maintaining genome integrity but also in
mediating the antitumor efficacy of DNA‐damaging antineoplastic drugs. Herein, we report …