Glyceryl trinitrate is administered as a provocative test for migraine pain. Glyceryl trinitrate
causes prolonged mechanical allodynia in rodents, which temporally correlates with …

Cranial allodynia associated with spontaneous migraine is reported as either responsive to
triptan treatment or to be predictive of lack of triptan efficacy. These conflicting results …

Despite intense investigation, the mechanisms of the different forms of trigeminal
neuropathic pain remain substantially unidentified. The transient receptor potential ankyrin 1 …

The TRPA1 receptor is a member of the transient receptor potential (TRP) family of ion
channels expressed in nociceptive neurons. TRPA1 receptors are targeted by pungent …

Migraine is a common neurological disorder often treated with triptans. Triptan overuse can
lead to increased frequency of headache in some patients, a phenomenon termed …

Objective.—To determine the effect of the 5‐HT2A receptor in control of spinal nociception,
cerebral circulation, and nitric oxide synthase (nNOS) expression in trigeminovascular …

The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized to a subpopulation of primary sensory neurons of the …

Although feverfew has been used for centuries to treat pain and headaches and is
recommended for migraine treatment, the mechanism for its protective action remains …

Background Clinical and experimental studies have pointed to the possible involvement of
the transient receptor potential ankyrin type-1 (TRPA1) channels in migraine pain. In this …

Activation of transient receptor potential ankyrin-1 (TRPA1) on meningeal nerve endings has
been suggested to contribute to environmental irritant–induced headache, but this channel …