Objectives This review addresses the common problem of missing patient-reported outcome
(PRO) data in clinical trials by assessing the current practice of their statistical handling as …

Background Missing patient reported outcomes data threaten the validity of PRO‐specific
findings and conclusions from randomized controlled trials by introducing bias due to data …

Background Public and government attention to patient-centered research outcomes has
been increasing, evidenced by the recent formation of the Patient Centered Outcomes …

Objective To compare the characteristics, quality and treatment effects of randomised clinical
trials (RCTs) by individual patient data (IPD) availability, in trials eligible for 18 IPD meta …

Although patient-reported outcomes (PROs), such as health-related quality of life, are
important endpoints in randomised controlled trials (RCTs), there is little consensus about …

Objective To assess analytic approaches randomized controlled trial (RCT) authors use to
address missing participant data (MPD) for patient-important continuous outcomes. Study …

Background Missing outcome data is a threat to the validity of treatment effect estimates in
randomized controlled trials. We aimed to evaluate the extent, handling, and sensitivity …

Background Missing outcome data is common in trials, and robust methods to address this
are needed. Most trial reports currently use methods applicable under a missing completely …

Background Patient-reported outcome (PRO) measures are critical for assessing treatment
benefit of anticancer treatments. Although PRO measures have been developed with the …

Background Individual patient data (IPD) meta-analysis is considered to be a gold standard
when the results of several randomized trials are combined. Recent initiatives on sharing …