Due to the poor solubility and bioavailability of 2-methoxyestradiol (2-ME), 2-ME emulsified
drug delivery system (2-ME-SEDDS) was designed and characterized. After dilution with 5 …

(1) Background: 2-Methoxyestradiol (2ME) is a metabolite of estrogens and possesses
promising anti-proliferative and cytotoxic activities. However, it suffers unfavorable …

This study sought to prepare a self-microemulsion drug delivery system containing
zingerone (Z-SMEDDS) to improve the low oral bioavailability of zingerone and anti-tumor …

The aim of the present study was to evaluate the pharmacokinetic and antitumor activity of 2-
methoxyestradiol (2-ME) nanosuspension relative to 2-ME solution both in vitro and in vivo …

The development of effective oral preparations of 2-methoxyestradiol (2-ME) has been a
worldwide problem. In this study, breakthrough progress has been made in oral delivery of 2 …

Injectable implant would be a potential way for 2-methoxyestradiol (2-ME) for the therapy of
breast cancer because of its water-insolubility, short half-life, and low oral bioavailability. So …

The purpose of the present study was to evaluate the tissue distribution and antitumor
activity of 2-methoxyestradiol (2-ME) nanosuspension compared with 2-ME solution both in …

Poor bioavailability of Docetaxel (DCT) arising due to its low aqueous solubility and
permeability limits its clinical utility. The aim of the present study was to develop DCT loaded …

Exemestane HCl (EXM) is a new irreversible steroidal aromatase inhibitor for adjuvant
therapy of hormonally sensitive breast cancer in post-menopausal women. EXM's low water …

Dissolving microneedle (DMN) has been researched as a drug delivery technology that
improves drug molecule transportation through the skin with little discomfort. However, the …