Misfolding and aggregation of disease-specific proteins, resulting in the formation of
filamentous cellular inclusions, is a hallmark of neurodegenerative disease with …

Dear Editor, Protein amyloid aggregation is a histological hallmark of neurodegenerative
diseases (NDs). 1, 2 In synucleinopathies including ParkinsonLs disease (PD), ParkinsonLs …

Proteins including FUS, hnRNPA2, and TDP-43 reversibly aggregate into amyloid-like fibrils
through interactions of their low-complexity domains (LCDs). Mutations in LCDs can …

Several studies using cryogenic electron microscopy (cryo-EM) techniques recently reported
the isolation and characterization of novel protein filaments, composed of a C-terminal …

Amyloid proteins, which are considered 'villains' in many neurodegenerative diseases, form
enigmatic pathological strains that underlie disease pathogenesis and progression. Recent …

Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's,
are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the …

TMEM106B, encoding a lysosome membrane protein, has been recently associated with
brain aging, hypomyelinating leukodystrophy and multiple neurodegenerative diseases …

Amyloid fibrils are protein homopolymers that adopt diverse cross-β conformations. Some
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …

Formation of fibrillar structures of proteins that deposit into aggregates has been suggested
to play a key role in various neurodegenerative diseases. However mechanisms and …

Neurodegenerative diseases are characterized by the formation and propagation of protein
aggregates, especially amyloid fibrils. However, what normally suppresses protein …